نتایج جستجو برای: isolated rat hepatocyte

تعداد نتایج: 602191  

Journal: :physiology and pharmacology 0
moslem najafi department of pharmacology, school of pharmacy, tabriz university of medical sciences, tabriz, iran saba ghaffary department of pharmacology, school of pharmacy, tabriz university of medical sciences, tabriz, iran elnaz shaseb department of pharmacology, school of pharmacy, tabriz university of medical sciences, tabriz, iran tahereh eteraf oskouei school of medicine, tabriz university of medical sciences, tabriz, iran

introduction: in the present study, potential differences between the effects of l-carnitine (lc) and acetyl-lcarnitine (alc) on ischemia/reperfusion (i/r)-induced myocardial infarction size were investigated. methods: male wistar rats were randomly divided into five groups and then anesthetized by sodium pentobarbital. hearts of the animals were removed and quickly mounted on a langendorff app...

Journal: :iranian journal of pharmaceutical sciences 0
shiva moghtadaee biopharmaceutics and pharmacokinetics division, department of pharmaceutics, faculty of pharmacy, tehran university of medical sciences,tehran, iran yalda hossein-zade ardakani biopharmaceutics and pharmacokinetics division, department of pharmaceutics, faculty of pharmacy, tehran university of medical sciences,tehran, iran hoda lavasani biopharmaceutics and pharmacokinetics division, department of pharmaceutics, faculty of pharmacy, tehran university of medical sciences,tehran, iran mohammadreza rouini biopharmaceutics and pharmacokinetics division, department of pharmaceutics, faculty of pharmacy, tehran university of medical sciences,tehran, iran

imatinib is an orally administered tyrosine kinase inhibitor which inhibits the bcr-abl protein-tyrosine kinase with high selectivity. imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. the metabolism of imatinib is mediated by the cytochrome p450 (cyp) isoenzymes in the liver and gut wall. cgp74588 is a major active metabolite of ima...

2011
Nripen S. Sharma Deepak Nagrath Martin L. Yarmush

The elucidation of the effect of extracellular matrices on hepatocellular metabolism is critical to understand the mechanism of functional upregulation. We have developed a system using natural extracellular matrices [Adipogel] for enhanced albumin synthesis of rat hepatocyte cultures for a period of 10 days as compared to collagen sandwich cultures. Primary rat hepatocytes isolated from livers...

There are several differentiation methods for mesenchymal stem cells (MSCs) into hepatocyte-like cell. Investigators reported various hepatic differentiation protocols such as modifying culturing conditions or using various growth factors/cytokines. In this literature review, we compared different MSCs extraction and isolation protocols from Wharton’s jelly (WJ) and explored various MSCs differ...

Journal: :The Biochemical journal 1986
M H Grant S J Smith M D Burke

The mixed-function-oxidase (MFO) activities, ethoxyresorufin and pentoxyphenoxazone O-dealkylase, of cultured Hooded-Lister(HL)-rat hepatocytes declined rapidly during 72 h of culture, whereas in Sprague-Dawley(SD)-rat hepatocytes the MFO activities increased between 24 and 72 h in culture. Cytochrome P-450 content declined at the same rate in both HL- and SD-rat hepatocyte cultures. NADPH:cyto...

Journal: :acta medica iranica 0
ali ghaffarian-bahraman department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. and department of toxicology and pharmacology, school of pharmacy, shiraz university of medical sciences, shiraz, iran. ibrahim shahroozian department of toxicology, school of veterinary medicine, university of semnan, semnan, iran. abbas jafari department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. and department of pharmacology and toxicology, school of pharmacy, urmia university of medical sciences, urmia, iran. mahmoud ghazi-khansari department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

the isolated perfused rat liver (iprl) model has been used into toxicology study of rat liver. this model provides an opportunity at evaluation of liver function in an isolated setting. studies showed that cd, in a dose-dependent manner, induced toxic effects in iprl models, and these effects were associated with aminotransferase activity and lipid peroxidation. the aim of this study was to inv...

Journal: :Cell structure and function 1993
A Masumoto N Yamamoto

A growth factor stimulating DNA synthesis of adult rat hepatocytes in primary culture was found in the conditioned medium after culturing nonparenchymal liver cells (NPC). Adding heparin to the NPC cultured medium stimulated the growth-factor secretion from NPC. The growth factor was secreted mainly by Kupffer cells. The partially purified growth factor from the NPC appeared to be related to th...

Journal: :Journal of lipid research 1994
R T Stravitz Z R Vlahcevic W M Pandak A Stolz P B Hylemon

In the bile acid biosynthetic pathways of humans and the rat, hepatic 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSDH) catalyzes the stereospecific reduction of the 3-oxo group of bile acid precursors. In addition, 3 alpha-HSDH may serve to shuttle bile acids from sinusoidal to apical (cannalicular) membranes of the rat hepatocyte. The objective of the present study was to define the molecul...

Journal: :Journal of biomedical materials research. Part A 2016
Abigail E Loneker Denver M Faulk George S Hussey Antonio D'Amore Stephen F Badylak

Whole organ engineering and cell-based regenerative medicine approaches are being investigated as potential therapeutic options for end-stage liver failure. However, a major challenge of these strategies is the loss of hepatic specific function after hepatocytes are removed from their native microenvironment. The objective of the present study was to determine if solubilized liver extracellular...

2014
Pierre Bonnaventure Catherine M. Pastor

To understand the transport function of drugs across the canalicular membrane of hepatocytes, it would be important to measure concentrations in hepatocytes and bile. However, these concentration gradients are rarely provided. The aim of the study is then to measure these concentrations and define parameters to quantify the canalicular transport of drugs through the multiple resistance associat...

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