To clarify the basis of increased left ventricular (LV) end-diastolic pressure associated with isometric exercise, LV diastolic and systolic function were examined in 25 patients during sustained handgrip. During handgrip, average systemic arterial mean pressure increased by 20 mm Hg, and LV systolic pressure rose by 31 mm Hg, though in five patients, no increase in mean arterial or LV systolic...

The purpose of this study was to document the cardiovascular response to submaximal isometric handgrip (IHG) exercise in 32 normal adolescents. Left ventricular (LV) dimensions and systolic time intervals were recorded using echocardiography; blood pressure was measured by sphygmomanometry both at rest and during IHG exercise at 25% maximum contraction. This level of isometric exercise produced...

infarction XII. Dynamic changes in segmental mechanical behavior of infarcted and non-infarcted myocardium. Am J Cardiol 37: 853, 1976 25. Baxley WA, Reeves TJ: Abnormal regional myocardial performance in coronary artery disease. Prog Cardiovasc Dis 8: 405, 1971 26. Bianco JA, Laskey WK, Makey DG, Schafer RB: Angiotensin infusion effects on left ventricular function. Chest 77: 172, 1980 27. Lud...

The effects of cold air inhalation and isometric exercise on coronary blood flow are currently unknown, despite the fact that both cold air and acute exertion trigger angina in clinical populations. In this study, we used transthoracic Doppler echocardiography to measure coronary blood flow velocity (CBV; left anterior descending coronary artery) and myocardial function during cold air inhalati...

Vasodilation occurs in the nonexercising forearm at the beginning of isometric handgrip despite activation of sympathetic vasoconstrictor reflexes. The mechanism of this response remains unclear. In 33 normal humans, age 24 +/- 1 years (mean +/- SEM), we measured mean arterial pressure, heart rate, and forearm blood flow (plethysmography) in the nonexercising arm during sustained contralateral ...

Background. Conventional strategies to treat myocardial ischemia include interventions that reduce oxygen demand and/or increase myocardial blood flow. Animal experiments suggest that right-shifting the hemoglobin-oxygen dissociation curve may also attenuate the metabolic consequences of myocardial ischemia. We evaluated whether exercise-induced myocardial ischemia can be alleviated in subjects...

The effect of isometric exercise by handgrip on the ejection dynamics of the left ventricle, especially the relation between left ventricular stroke work index and end-diastolic pressure, was studied in 25 patients. In the patients with normal or nearly normal left hearts (group i), the response to handgrip was characterized by a significant increase of left ventricular stroke work index at an ...

Although resting hemodynamic load has been extensively investigated as a determinant of left ventricular (LV) hypertrophy, little is known about the relationship between provoked hemodynamic load and the risk of LV hypertrophy. We studied central pressure-flow relations among 40 hypertensive and 19 normotensive adults using carotid applanation tonometry and Doppler echocardiography at rest and ...

OBJECTIVE Little is known regarding whether exercise-induced hypoalgesia (EIH) produced by isometric exercise is influenced by psychological factors or systematically varies across multiple experimental psychophysical pain tests. Thus, this study sought to determine the influence of experimental pain test, psychological factors, and sex on the hypoalgesic response of submaximal isometric exerci...

BACKGROUND The risk of developing cardiovascular disease is directly correlated to one's resting blood pressure (BP), age, and biological sex. Resting BP can be reduced using handgrip exercise training, but the impact of age and sex on the effectiveness of training is not well documented. METHODS/DESIGN A systematic search of the literature will be conducted for all experimental studies (incl...