The basic steps of a RRQR Factorization are: (i) select columns from the input matrix A, (ii) permute them to leading positions to a new matrix Ap, (iii) compute a QR Factorization Ap = QR, (iv) reveal rank(A) from R. Since their introduction [1, 2], algorithmic trends have involved procedures for deterministically selecting columns from A [3, 4, 5]. Motivated by recent results in theoretical c...

BACKGROUND Although the methodological quality of therapeutic guidelines (GLs) has been criticized, little is known regarding the quality of GLs that make diagnostic recommendations. Therefore, we assessed the methodological quality of GLs providing diagnostic recommendations for managing diabetes mellitus (DM) and explored several reasons for differences in quality across these GLs. METHODS ...

We describe different procedures to deal with measurement error in linear models, and assess their performance in finite samples using Monte Carlo simulations, and data on corporate investment. We consider the standard instrumental variables approach proposed by Griliches and Hausman (1986) as extended by Biorn (2000) [OLS-IV], the Arellano and Bond (1991) instrumental variable estimator, and t...

Two linear estimators for stationary invertible vector autoregressive moving average (VARMA) models in echelon form – to achieve parameter unicity (identification) – with known Kronecker indices are studied. It is shown that both estimators are consistent and asymptotically normal with strong innovations. The first estimator is a generalized-least-squares (GLS) version of the two-step least-squ...

Many transformed cells exhibit altered glucose metabolism and increased utilization of glutamine for anabolic and bioenergetic processes. These metabolic adaptations, which accompany tumorigenesis, are driven by oncogenic signals. Here we report that the transcription factor c-Jun, product of the proto-oncogene JUN, is a key regulator of mitochondrial glutaminase (GLS) levels. Activation of c-J...

INTRODUCTION Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, and aberrant GLS production has been observed in the active synovial membranes of rheumatoid arthritis (RA) patients. The human GLS gene promoter contains at least seven consensus binding sites for the DNA binding protein Sp1. Here we examined whether Sp1 is necessary for GLS production in RA. ...

Guided Local Search (GLS) is a general meta-heuristic that sits on top of local search algorithms and help them escape from local minima. However, GLS is often trapped in a small local area. Estimation of Distribution Algorithm(EDA) is a new evolutionary algorithm in which statistical information are explicitly extracted from the current population and then used for generating new solutions. Th...

Granular lymphocytes (GLs) in patients with GL-proliferative disorders (GLPDs) are known to express the interleukin-2 receptor (IL-2R) p chain (p70-75) constitutively and to proliferate in response to stimulation with IL-2 via the p chain. In this report, we found that the anti-CD3 monoclonal antibody (MoAb) OKT3 could induce the proliferation of GLs from patients with T-cell lineage GLPDs (T-c...

AIMS While abnormal resting LV GLS has been described in patients with chronic heart failure with preserved ejection fraction (HFpEF), its prognostic significance when measured during an acute heart failure hospitalization remains unclear. We assessed the association between left ventricular global longitudinal strain (LV GLS) and outcomes in patients hospitalized with acute HFpEF. METHODS AN...

This paper deals with four types of point estimators based on minimization of informationtheoretic divergences between hypothetical and empirical distributions. These were introduced (i) by Liese & Vajda (2006) and independently Broniatowski & Keziou (2006), called here power superdivergence estimators, (ii) by Broniatowski & Keziou (2009), called here power subdivergence estimators, (iii) by B...