GPU computing has rapidly gained popularity as a way to achieve higher performance of many scientific applications. In this paper we report on the experience of porting a hybrid MPI+OpenMP molecular dynamics code to a GPU enabled CrayXK7 to make a hybrid MPI+GPU code. The target machine, Indiana University’s Big Red II, consists of a mix of nodes equipped with two 16-core Abu Dhabi X86-64 proce...

The N-terminal tail of histone H2B is believed to be involved in gene silencing, but how it exerts its function remains elusive. Here, we report the biochemical characterization of p14ARF tumor suppressor as a transcriptional repressor that selectively recognizes the unacetylated H2B tails on nucleosomes. The p14ARF-H2B tail interaction is functional, as the antagonistic effect of p14ARF on chr...

The postdoc position will be associated with the Computer Science Laboratory at Ecole Polytechnique (LIX) and will be supervised by Dominique Rossin, Eric Goubault, Samuel Mimram and Emmanuel Haucourt. The lab is composed of about a hundred researchers, and is associated with CNRS and INRIA through joint research projects. Ecole Polytechnique is one of the most famous engineering schools in Fra...

Histone lysine methylation plays a critical role in epigenetic regulation of eukaryotes. To date, studies have shown that lysine residues of K4, K9, K27, K36 and K79 in histone H3 and K20 in histone H4 can be modified by histone methyltransferases (HMTs). Such histone methylation can specifically activate or repress the transcriptional activity to play a key role in gene expression/regulation a...

Simple epithelial keratins (SEKs) are found primarily in single-layered simple epithelia and include keratin 7 (K7), K8, K18-K20, and K23. Genetically engineered mice that lack SEKs or overexpress mutant SEKs have helped illuminate several keratin functions and served as important disease models. Insight into the contribution of SEKs to human disease has indicated that K8 and K18 are the major ...

Hexavalent chromium [Cr(VI)] is a soluble carcinogen that has caused widespread contamination of soil and water in many industrial nations. Bacteria have the potential to aid remediation as certain strains can catalyze the reduction of Cr(VI) to insoluble and less toxic Cr(III). Here, we examine Cr(VI) reducing Microbacterium spp. (Cr-K1W, Cr-K20, Cr-K29, and Cr-K32) isolated from contaminated ...