Understanding virulence is vital for the development of novel therapeutics to target infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), which cause an ongoing epidemic in the United States and are on a global rise. However, what defines virulence particularly of global CA-MRSA lineages is poorly understood. Threatening a vast population, the predominant ...

In this study, we used patient-specific and isogenic PARK2-induced pluripotent stem cells (iPSCs) to show that mutations in PARK2 alter neuronal proliferation. The percentage of TH(+) neurons was decreased in Parkinson's disease (PD) patient-derived neurons carrying various mutations in PARK2 compared with an age-matched control subject. This reduction was accompanied by alterations in mitochon...

Background: Lactococcus garvieae causes lactococcosis in rainbow trout in many parts of the world. Aims: This study was conducted for the existence of the virulent factors and differentiation of the two serotypes in L. garvieae. Methods: Twenty-two strains of L. garvieae isolated from diseased rainbow trout from farms...

Total flower and pod numbers (TFPN) effective per plant (PNPP) are among the most important agronomic traits for soybean production. However, underlying genetic mechanism remains unclear. In this study, we constructed a recombinant inbred line population derived from cross between JY73 (high TFPN) TJSLH (low to map loci two traits. total, six QTL TFPN five PNPP were identified, which on chromos...

BACKGROUND: Escherichia coli (E.coli) is one of the most common and important causative bacterium of urinary tract infections (UTIs) in both dogs and humans. OBJECTIVES: This study aimed to identify virulence genes and a phylogenetic group of E. coli isolated from the urine of dogs suffering from UTIs. METHODS: <em...

Haemophilus influenzae requires an exogenous heme source for aerobic growth in vitro. Hemoglobin or hemoglobin-haptoglobin satisfies this requirement. Heme acquisition from hemoglobin-haptoglobin is mediated by proteins encoded by hgp genes. Both Hgps and additional proteins, including those encoded by the hxu operon, provide independent pathways for hemoglobin utilization. Recently we showed t...

pasteurella multocida is an opportunistic pathogen responsible for pneumonia of lambs and goats, respiratory atrophic rhinitis of swine. although the molecular basis of the pathogenicity and host specificity of p. multocida is not well understood, several studies have reported that a number of proteins are correlated with the pathogenic mechanisms. adhesins have a crucial role in mediating colo...

The development of aluminum (Al)-tolerant cultivars is a complementary strategy to overcome the constraints caused by Al toxicity on acid soils and can contribute positively food supply for growing global population. A major tolerance quantitative trait locus in maize controlled citrate transporter encoded ZmMATE1. Our goal was evaluate impact superior allele ZmMATE1 yield performance lines hyb...