نتایج جستجو برای: keywords mefenamic acid

تعداد نتایج: 2689084  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2013
Howard Horng Leslie Z Benet

Mefenamic acid (MFA), a carboxylic acid-containing nonsteroidal anti-inflammatory drug, is metabolized into the chemically-reactive MFA-1-O-acyl-glucuronide (MFA-1-O-G), MFA-acyl-adenylate (MFA-AMP), and the MFA-S-acyl-coenzyme A (MFA-CoA), all of which are electrophilic and capable of acylating nucleophilic sites on biomolecules. In this study, we investigate the nonenzymatic ability of each M...

2004
Sulekha Bhadra Manoj Kumar Sunil Jain Shikha Agrawal G. P. Agrawal

*To whom all correspondence should be addressed. he quality of a solid pharmaceutical preparation is influenced by primary micromeritic characteristics such as the shape and size of drug crystals, especially when large amounts of poorly soluble drugs are formulated. To improve the dissolution rate of poorly soluble drugs, fine crystals are preferred over large crystals because they provide a gr...

2014
Reza Heidarifar Nahid Mehran Akram Heidari Hoda Ahmari Tehran Mohammad Koohbor Mostafa Kazemian Mansourabad

BACKGROUND Dysmenorrhea has negative effects on women's life. Due to side-effects of chemical drugs, there is growing trend toward herbal medicine. The aim of this study was to assess the effect of Dill compared to mefenamic acid on primary dysmenorrhea. MATERIALS AND METHODS This double-blind, randomized, clinical trial study was conducted on 75 single female students between 18 and 28 years...

2016
Maryam Alsadat Hashemipour Hoda Mehrabizadeh Honarmand Farideh Falsafi Mehrnaz Tahmasebi Arashlo Saied Rajabalian Sayed Amir Hossein Gandjalikhan Nassab

STATEMENT OF THE PROBLEM Use of cyclooxygenase inhibitors as chemotherapy agents has attracted the attention of a large number of investigators in recent years. Given the importance of cancer therapy, only a limited number of studies have been carried out to investigate the effects of cyclooxygenase inhibitors on specific cell lines. PURPOSE This research aimed to determine the in vitro cytot...

Journal: :The Analyst 1998
P C Ioannou N V Rusakova D A Andrikopoulou K M Glynou G M Tzompanaki

Terbium sensitized fluorescence was used to develop a sensitive and simple spectrofluorimetric method for the determination of the anthranilic acid derivatives furosemide and mefenamic and tolfenamic acids. The method makes use of radiative energy transfer from anthranilates to terbium ions in alkaline methanolic solutions. Optimum conditions for the formation of the anthranilate-Tb3+ complexes...

Journal: :Analytical biochemistry 2012
Anne-Laure Gagez Koukeb Rouguieg-Malki François-Ludovic Sauvage Pierre Marquet Nicolas Picard

This article describes the development of a procedure for the simultaneous evaluation of the activity of six different uridine diphosphate (UDP)-glucuronyltransferases (UGTs) in human liver microsomes (HLMs). The method consists of incubations of probe substrates for UGT1A1 (etoposide), UGT1A3 (chenodeoxycholic acid), UGT1A4 (trifluoperazine), UGT1A6 (serotonin), UGT1A9 (mefenamic acid), and UG...

Journal: :Journal of alternative and complementary medicine 2009
Giti Ozgoli Marjan Goli Fariborz Moattar

OBJECTIVES To compare the effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. METHODS This was a double-blind comparative clinical trial conducted from September 2006 to February 2007. Participants were 150 students (18 years old and over) with primary dysmenorrhea from the dormitories of two medical universities who were alternately divided into three...

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