BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been studied in detail. Here we demonstrate that BAG-1 overexpression completely prote...

With the rise of Social Media, people obtain and share information almost instantly on a 24/7 basis. Many research areas have tried to gain valuable insights from these large volumes of freely available user generated content. The research areas of intelligent transportation systems and smart cities are no exception. However, extracting meaningful and actionable knowledge from user generated co...

bananas are climacteric fruits and controlling ripening is effective in reducing loss. this experiment studied the effect of packaging (plastic bag, edible wax and plastic bag, plastic bag and 2 or 4 g/kg potassium permanganate) over 5 weeks of cold storage on the quality and characteristics of cavendish cultivar bananas. the samples were removed from storage at 8, 16, 24, 32 and 40 days and fr...

The bag radius of the nucleon can be determined by MIT bag model based on electric and magnetic form factors of the nucleon. Also we determined the masses and magnetic moment of the nucleon with MIT bag model, using bag radius and compared with other results, suggests a suitable compatibility. Keywords—MIT bag model, masses and magnetic moment of the nucleon, bag radius of the nucleon.

Letter names are stressed in informal and formal literacy instruction with young children in the US, whereas letters sounds are stressed in England. We examined the impact of these differences on English children of about 5 and 6 years of age (in reception year and Year 1, respectively) and US 6 year olds (in kindergarten). Children in both countries spelled short vowels, as in bag, more accura...

Pediatric ophthalmologists increasingly recognize that the ideal site for intraocular lens (IOL) implantation is in the bag for aphakic eyes, but it is always very difficult via conventional technique. We conducted a prospective case series study to investigate the success rate and clinical outcomes of capsular bag reestablishment and in-the-bag IOL implantation via secondary capsulorhexis with...

The C-terminal BAG domain is thought to play a key role in BAG-1-induced survival and proliferation by mediating protein-protein interactions, for example, with heat shock proteins HSC70 and HSP70, and with RAF-1 kinase. Here, we have identified thioflavin S (NSC71948) as a potential small-molecule chemical inhibitor of these interactions. NSC71948 inhibited the interaction of BAG-1 and HSC70 i...