The objective of this study was to investigate the role of calmodulin-dependent protein kinase II (CaMKII) during fertilization in the pig. Since it has been reported that CaMKII is involved in the capacitation and acrosome reaction of spermatozoa, we tested whether supplementation with the CaMKII inhibitor, KN-93, in the fertilization medium affected sperm penetration. The results showed that ...

Learning and memory have been suggested to be important in the development of opiate addiction. Based on the recent findings that calcium/calmodulin-dependent protein kinase II (CaMKII) is essential in learning and memory processes, and morphine treatment increases CaMKII activity in hippocampus, the present study was undertaken to examine whether inhibition of hippocampal CaMKII prevents morph...

For double arrays of constants {ani, 1 ≤ i ≤ kn, n ≥ 1} and sequences of negatively orthant dependent random variables {Xn, n ≥ 1}, the conditions for strong law of large number of ∑kn i=1 aniXi are given. Both cases kn ↑ ∞ and kn = ∞ are treated.

Let r(G,H) be the smallest integer N such that for any 2-coloring (say, red and blue) of the edges of Kn, n > N there is either a red copy of G or a blue copy of H . Let Kn − K1,s be the complete graph on n vertices from which the edges of K1,s are dropped. In this note we present exact values for r(Km −K1,1,Kn −K1,s) and new upper bounds for r(Km,Kn−K1,s) in numerous cases. We also present som...

Diameter of the 2 k-node Knn odel graph is d(k + 2)=2e:

Authors have previously shown that alpha-mercaptopropionylglycine (alpha-MPG) and sodium dipropylacetate (DPA) facilitate immunity as well as host-mediated anti-tumor activity. In this study, we found that a compound related to alpha-MPG and DPA, (2-n-propyl-n-pentanoyl)glycine (KN-539), inhibited the growth of E.L.4 lymphosarcoma transplanted in C57BL/6 mice and further investigated the anti-t...

We construct a new family {Kn} of simply connected symplectic 4-manifolds with the property c1(Kn)/χh(KN ) → 9 (as n → ∞).

Among bovine rotavirus strains, there are three G serotypes (G6, G8, and G10) and three P (VP4) serotypes (PB1, PB2, and PB3, which are defined on the basis of strains NCDV, UK, and B223, respectively). Plaque reduction neutralization assays with hyperimmune antisera disclosed two-way antigenic relationships of strain KN-4 with strain KK-3 (G10, PB3) as well as with strains NCDV (G6, PB1) and 0...

Let n ≥ 2 be an integer. The complete graph Kn with a 1-factor F removed has a decomposition into Hamilton cycles if and only if n is even. We show that Kn − F has a decomposition into Hamilton cycles which are symmetric with respect to the 1-factor F if and only if n ≡ 2, 4 mod 8. We also show that the complete bipartite graph Kn,n has a symmetric Hamilton cycle decomposition if and only if n ...

The altitude of a graphG, denoted f(G), is the largest integer k such that under each ordering of E(G), there exists a path of length k which traverses edges in increasing order. In 1971, Chvátal and Komlós asked for f(Kn), where Kn is the complete graph on n vertices. In 1973, Graham and Kleitman proved that f(Kn) ≥ √ n− 3/4− 1/2 and in 1984, Calderbank, Chung, and Sturtevant proved that f(Kn)...