نتایج جستجو برای: knoevenagel condensation
تعداد نتایج: 32510 فیلتر نتایج به سال:
An efficient one-pot three-component protocol for the synthesis of novel tetrahydrobenzofuran-chromone conjugates using 3-formylchromones and 1,3-cyclohexandiones in presence a variety alkyl or aryl isocyanides was developed. The reaction sequence consists an initial Knoevenagel condensation aromatic aldehydes with 1,3-cyclohexandione derivatives, followed by [4 + 1] cycloaddition isocyanides, ...
Coumarin and its derivatives represent one of the most active curriculums compound possessing a broad spectrum biological activity along with other applications such as insecticide fragrance. There are various methodologies developed for synthesis coumarins. Classical routes to coumarins include Pechmann condensation, Knoevenagel Perkin reaction, Wittig condensation reactions. Researchers have ...
All-trans retinoic acid (10) was synthesized by β-ionone (5) through knoevenagel condensation, reduction and hydrolysis reaction. Then, hydroxyl-pinacolone retinoate (11) prepared the esterification with 1-hydroxy- 3, 3-dimethylbutan-2-ketone. This route not only reduces synthesis steps but also helps to increase yield. The structure of product characterized 1 H NMR 13 C NMR.
A ligand free, Palladium nanoparticles catalyzed synthesis of pyran derivatives using C-H activated compound, malononitrile and aryl aldehyde via Knoevenagel condensation followed by Michael addition reaction using Palladium nanoparticles as catalyst in one-pot is described herein. The advantages of this method lie in its simplicity, low catalyst loading, cost effectiveness and easy to handle. ...
BACKGROUND The pyrazolyl ketone motif of RO3201195, which exhibits good oral bioavailability and high selectivity for p38 MAPK over other kinases, is a key pharmacophore that could find application in the treatment of Werner syndrome. RESULTS AND DISCUSSION Microwave irradiation promotes Knoevenagel condensation of a β-ketonitrile and formamidine, to give β-aminovinyl ketones, and their subse...
BACKGROUND Synthesized arylidene derivatives of rhodanine and 2,4-thiazolidiendione have potent pharmacological activities, and these are also key substrates for the preparation of clinically used antidiabetics. FINDINGS Some 1,1,3,3-tetramethylguanidine-based task-specific ionic liquids (TSILs) 1a-1e were prepared and employed to the catalyzed solvent-free Knoevenagel condensation of 2,4-thi...
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