In a Phase III trial for HER2-positive breast cancer (the CLEOPATRA study), the triple-drug combination arm of pertuzumab plus trastuzumab plus docetaxel showed significantly longer progression-free survival and overall survival than did the trastuzumab plus docetaxel arm. In this study, we investigated the mechanism of action of the triple-drug combination therapy in vivo. For this purpose, we...

We investigated the potential of the pH-sensitive dye, CypHer5E, conjugated to Herceptin (pH-Her) for the sensitive detection of breast tumors in mice using noninvasive time-domain near-infrared fluorescence imaging and different methods of data analysis. First, the fluorescence properties of pH-Her were analyzed as function of pH and/or dye-to-protein ratio, and binding specificity was confirm...

The information available to modern autonomous systems is often in the form of streams. As the number of sensors and other stream sources increases there is a growing need for incremental reasoning about the incomplete content of sets of streams in order to draw relevant conclusions and react to new situations as quickly as possible. To act rationally, autonomous agents often depend on high lev...

Acid mine drainage can be generated by coal stockpile piles, especially if the sulfur content is high which have an impact on environmental health. The of runoff water pollution overcome treating wastewater using phytoremediation. author conducted a phytoremediation experiment Echinodorus palaefolius plants with samples taken from inlet KPL C PT Bukit Asam Tbk Unit Dermaga Kertapati in June - A...

The paper considers the results of application photogrammetry to assess deformations rod and plate elements steel constructions hoisting machines, analysis main problems arising in their processing proposed solutions ensure necessary accuracy. authors, based on own research practical experiences use photogrammetry, carried out accuracy rating magnitude deformations. Based a brief review normati...

multiple traveling salesman problem (mtsp) is one of the most popular operation research problem and is known as combinatorial optimization problems. mtsp is an extension version of the famous and widely used problem named traveling salesman problem (tsp). because of its benefices in various domains, many researchers have tried to solve that, and many methods have proposed so far. mtsp is a np-...

cardiovascular diseases are one of the most common diseases that cause a large number of deaths each year. coronary artery disease (cad) is the most common type of these diseases worldwide and is the main reason of heart attacks. thus early diagnosis of cad is very essential and is an important field of medical studies. many methods are used to diagnose cad so far. these methods reduce cost and...