The nuclease is a surface enzyme unique to trypanosomatid parasites. These organisms lack the pathway for de novo purine biosynthesis and thus are entirely dependent upon their hosts to supply this nutrient for their survival, growth, and multiplication. There is a cluster on chromosome 30 which carries 2 copy of nuclease genes and 5 identical nuclease like proteins in L. major which are in cis...

The amino acid L-arginine plays a crucial role in the regulation of immune responses. We have recently shown that uncontrolled replication of Leishmania parasites at the site of pathology correlates with high levels of arginase activity in nonhealing leishmaniasis and that this elevated arginase activity causes local depletion of L-arginine. To further our understanding of the impact of L-argin...

This study focuses on lead detoxification using roots, stems, leaves and whole plants of Plantago major L. and Phaseolus vulgaris L. (decoration kidney bean) as a ball hanging hydroponically in deionized water supplemented with concentrations of lead ion under different duration times and temperatures regimes. Roots of studied plants showed that the highest removal of lead than other parts, whi...

background cutaneous leishmaniasis (cl) with diverse clinical manifestations is prevalent and remains a major public health problem in iran, while its incidence has been doubled over the last decade. this study was performed for the first time in larestan, fars province, located in southern part of iran to determine infectious patterns in the reservoir hosts and sand fly vectors using parasitol...

Background: The seeds of some medicinal plants and their compounds have long been valued for their numerous health benefits. Objective:To investigate some physical and chemical properties of Salvia spp. Methods: Some physico-chemical properties in five species of Salvia seeds (consisted of S. officinalis L., S. macrosiphon L., S. hypoleuca L., S. sclarea L. and S. nemorosa L.) were measured ...

Background: Cutaneous leishmaniasis is a common parasitic disease in Iran being mainly caused by Leishmania (L.) major. The aim of this study was to investigate the occurrence of apoptosis in the spleen and liver of female mice infected with L. major.Methods: BALB/c mice were randomly assigned into the control and experimental groups (ten mice per group). The experimental groups were subcutaneo...

from the aerial parts of tanacetum balsamita l. (compositae) a flavonol aglycon was iso­lated using chromatographic techniques. the structure of this compound was determined using spectroscopic methods (uv, h-nmr and ms) as 3',4',5,7-tetrahydroxy flavonol (quercetin).