The aging midface has long been overlooked in cosmetic surgery. Our understanding of facial aging in terms of 3 dimensions has placed increased importance on volume restoration. Although an "off-label" indication for most fillers in this facial region, volumization of the midface with injectable fillers is usually a safe and straightforward procedure technically. Injectors, nevertheless, need t...

Drug therapy is a powerful tool for improving neonatal outcome. Despite this, neonatologists still routinely prescribe off-label compounds developed for adults and extrapolate doses from those used for children or adults. Knowledge integration through pharmacokinetic modeling is a method that could improve the current situation. Such predictive models may convert neonatal pharmacotherapy from e...

OBJECTIVES To assess patients' knowledge of their drug therapy for neovascular macular degeneration and to identify which aspects of the drug they considered most important if given the option of switching to an alternative drug. DESIGN Prospective questionnaire survey. SETTING Wolverhampton, England. PARTICIPANTS A total of 126 patients attending our hospital service for intravitreal ran...

In spite of increased awareness and the efforts taken to optimize Clostridium difficile infection (CDI) management, with the limited number of currently available antibiotics for C. difficile the halt of this increasing epidemic remains out of reach. There are, however, close to 80 alternative treatment methods with controversial anti-clostridial efficacy or in experimental phase today. Indeed,...

BACKGROUND The lack of availability of appropriate medicines for children is an extensive and well known problem. Paediatricians and Physicians who take care of the paediatric population are primarily exposed to cope with this negative situation very often as more than half of the children are prescribed off-label or unlicensed medicines. DISCUSSION Medicinal products used to treat this popul...

The practice of off-label prescribing, i.e. prescribing drugs either for unregistered/unapproved therapeutic indications and age groups or using unregistered/unapproved doses or methods of administration, is common in older patients. This may be due to the poor representation of this group in pre-marketing clinical trials assessing therapeutic efficacy and safety of novel therapies or merely to...

ÖzetZamanında tedavi edilmemiş geniş patent duktus arteriozus ve önemli pulmoner hipertansiyonu bulunan hastalar kardiyologlar için önemli bir sorundur. Bu hastalarda kateter laboratuvarında uygulanan reverzibilite ve balon oklüzyon testleri hastanın sonraki planlaması için karar vermede yardımcı olabilir. Kateter yoluyla duktusun kapatılması planlanan hastalarda bu amaçla geliştirilmiş cihazla...

BACKGROUND Chronic spontaneous urticaria (CSU) is a common, debilitating disease that is frequently resistant to standard therapy. Omalizumab, anti-immunoglobulin-E humanized monclonal antibody, was recently shown to be effective in treating resistant CSU. OBJECTIVES To investigated the treatment of CSU with omalizumab in Israel. METHODS We conducted a multicenter retrospective analysis of ...

‎let $g$ be a graph with vertex set $v(g)$ and edge set $x(g)$ and consider the set $a={0,1}$‎. ‎a mapping $l:v(g)longrightarrow a$ is called binary vertex labeling of $g$ and $l(v)$ is called the label of the vertex $v$ under $l$‎. ‎in this paper we introduce a new kind of graph energy for the binary labeled graph‎, ‎the labeled graph energy $e_{l}(g)$‎. ‎it depends on the underlying graph $g$...