Sir, The New Delhi metallo-lactamase (NDM), initially reported in Klebsiella pneumoniae and Escherichia coli, is now disseminated worldwide mostly among Enterobacteriaceae [1]. The NDM carbapenemase has also been described in Acinetobacter baumannii, but only in sporadic cases in countries such as China, India, Egypt, Germany, Israel and, more recently, Brazil [1,2]. Noteworthy, recent studies ...

A Pseudomonas aeruginosa é uma bactéria oportunista, considerada um dos principais agentes de infecção nosocomial em hospitais associada múltipla resistência a antimicrobianos. Em animais, principalmente cães, otite enfermidade grande incidência associado P. aeruginosa. ocorrência isolados multirresistentes metalo beta lactamase com presença genes blaIMP-1, blaVIM-2, blaSPM-1 e blaNDM-1 tem sid...

A carbapenem-resistant Citrobacter freundii strain WCHCF65 was recovered from hospital sewage and was characterized by genome sequencing and conjugation experiments. The strain carried nine genes encoding β-lactamases including two carbapenemase genes, blaNDM-1 and blaKPC-2. blaNDM-1 was carried on an IncX3 plasmid, which was identical to a plasmid found in a local Escherichia coli, suggesting ...

Sir, Recently, a new carbapenemase, NDM-1, encoded by blaNDM-1, has become a global concern. Previous work reported the prevalence of blaNDM-1 mainly in animal-associated and human-associated bacteria (e.g. patients and animals – ). Walsh et al. detected blaNDM-1 in seepage samples and drinking water, indicating the dissemination of blaNDM-1 in the environment. Soil, one of the largest natural ...

Although coexistence of blaNDM-5 and mcr-1 in Escherichia coli has been reported, little is known about the fitness and virulence of such strains. Three carbapenem-resistant Escherichia coli (GZ1, GZ2, and GZ3) successively isolated from one patient in 2015 were investigated for microbiological fitness and virulence. GZ1 and GZ2 were also resistant to colistin. To verify the association between...

Escherichia coli isolates from various sources 2018 to 2019 were included in the study. Mcr-1 genes found two of 105 animal strains (2%) and seven 928 human (0.8%). All mcr-1-positive showed a low level resistance colistin (MIC ranged 4 8 µg/ml). Both isolated animals remained sensitive betalactam antibiotics did not contain beta-lactamase genes. Beta-lactamases absent only one humans. Four res...

results the most effective agent against the studied isolates was colistin. by cddt, it was found that among 278 imipenem resistant p. aeruginosa strains, 178(64.02%) were mbl producers. the blaimp-1 and blavim-1 genes were detected in 30(16.8%) and 52(29.2%) of p. aeruginosa isolates, respectively. result of 187 imipenem resistance a. baumannii strains showed that 85(45.4%) were mbl producers....

Enterobacteriaceae with blaNDM-7 are relatively uncommon and had previously been described in Europe, India, the United States, and Japan. This study describes the characteristics of Enterobacteriaceae (Klebsiella pneumoniae [n = 2], Escherichia coli [n = 2], Serratia marcescens [n = 1], and Enterobacter hormaechei [n = 1] isolates) with blaNDM-7 obtained from 4 patients from Calgary, Canada, f...

We report here the draft genome sequence of uropathogenic Escherichia coli sequence type 648 (ST648) possessing blaNDM-5 from a 55-year-old female in Australia with a history of travel to India. The plasmid-mediated blaNDM-5 was in a genetic context nearly identical to that of the GenBank entry of an IncX3 blaNDM-5 plasmid previously reported from India (Klebsiella pneumoniae MGR-K194).

1. Queenan AM, Bush K. Carbapenemases: the versatile β-lactamases. Clin Microbiol Rev. 2007;20:440–58. DOI: 10.1128/ CMR.00001-07 2. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: 20th informational supplement (update 2010 Jun). Document M100–S20-U. Wayne (PA): The Institute; 2010. 3. Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, ...