Failed back surgery syndrome (FBSS) is a prevalent, debilitating condition that affects the quality of life of many patients. The role of peridural fibrosis in FBSS continues to be a source of controversy. The authors report an association between peridural fibrosis and tactile allodynia, but not neurological dysfunction in a rodent cauda equine crush injury model. Methods Twenty-one rats were ...

Metallothionein (MT) is a small molecular weight protein possessing metal binding and free radical scavenging properties. We hypothesized that MT-1/MT-2 null (MT(-/-)) mice would display exacerbated soleus muscle atrophy, oxidative injury, and contractile dysfunction compared with the response of wild-type (WT) mice following acute spinal cord transection (SCT). Four groups of mice were studied...

management of spinal cord or cauda equina compression from recurrent primary or secondary malignancies was not discussed. (6) The critical role of dexamethasone in emergency treatment was not mentioned. (7) Chemotherapy now has a central role in the management of intraspinal malignancy,S yet receives no mention whatever. If a specific diagnosis can be made by biopsy (of the cord compressing les...

Cervical spondylotic myelopathy is the most common spinal cord disorder in persons over 55 years of age in North America and perhaps in the world. Surgical options are broadly classified into two categories namely, anterior and posterior approaches. This study focuses on the posterior based approach (i.e. laminectomy or laminoplasty) which is considered when multiple levels of the spine have to...

Epidural fibrosis is an extradural scar tissue formed after a laminectomy procedure. It is associated with persistent pain after spinal surgery and an increased risk of complications during revision surgery. The aim of this study was to determine the preventive effects of local application of an omental free graft in minimising spinal epidural fibrosis in a rabbit laminectomy model. Twenty two ...

OBJECTIVE To establish normative data for spinal canal AP diameter from cervical vertebra to sacrum in the Korean young and to assess the exposed spinal canal after laminectomy which was related with restenosis by post-laminectomy membrane formation. METHODS From PET/CT, axial bone-window CT of 83 young adults (20-29 years) were obtained, and we measured AP diameters of C3, C5, C7, T1, T4, T8...

RATIONALE Severe post-laminectomy spinal deformity associated with late-onset paraplegia is a complex and rare disorder. Little is known about revision surgery in post-laminectomy rotokyphoscoliosis associated with late-onset paraplegia treated by the single stage posterior-only vertebral column resection (VCR) procedure. PATIENT CONCERNS AND DIAGNOSES The patient was a 14-year-old male diagn...

It is thirty-seven years since Mixter and Barr (1934) presented their classical paper on the surgical treatment of ruptured intervertebral discs. In 1941 they published the short-term results in ninety-four patients with lumbar lesions. They showed that fusion of the spine at the time of laminectomy lowered the incidence of subsequent back symptoms and concluded that laminectomy weakened the ba...

OBJECT The objective of this systematic review was to use evidence-based medicine to compare the efficacy of different surgical techniques for the treatment of cervical spondylotic myelopathy (CSM). METHODS The National Library of Medicine and Cochrane Database were queried using MeSH headings and keywords relevant to anterior and posterior cervical spine surgery and CSM. The guidelines group...