Microelectrode technics were used to study effects of ouabain (0), 2 x 10-7 moles/liter, on phase 4 of Purkinje fiber (PF) transmembrane potentials (TMP). Perfusion for 25-35 min with 0 caused an increase in phase 4 depolarization which resulted in either increased automaticity or occurrence of low-amplitude potentials (LAP). Increased automaticity was more frequent when PF had been stretched, ...

This document’s goal is to interpret Soltys’ theory LAp [SK01, SC04] two times. Once over the field F2 into the theory V⊕L, and once over the integral domain Z into the theory V#L [Fon09]. Both theories capture basic arithmetic and include a function expressing matrix powering. Each interpretation is a mapping from LAp to V⊕L (respectively, V#L) of terms and formulas such that provability is pr...

BACKGROUND Listeria monocytogenes, an intracellular foodborne pathogen, infects immunocompromised hosts. The primary route of transmission is through contaminated food. In the gastrointestinal tract, it traverses the epithelial barrier through intracellular or paracellular routes. Strategies to prevent L. monocytogenes entry can potentially minimize infection in high-risk populations. Listeria ...

In this study the pacing strategy, cycle characteristics and choice of technique of elite male cross-country (XC) skiers during a three-lap, 15-km classical race with interval start were measured. During the Norwegian Championships in 2016, fast (n = 18, age: 26±4 yr; height: 182±4 cm; body mass: 78±3 kg (means±SD)) and slow skiers (n = 18, age: 22±2 yr; height: 183±5 cm; body mass: 78±6 kg) we...

Intracellular accumulation of polyglutamine (polyQ)-expanded Huntingtin (Htt) protein is a hallmark of Huntington's disease (HD). This study evaluated whether activation of Sirt1 by the anti-cancer agent, β-lapachone (β-lap), induces autophagy in human neuroblastoma SH-SY5Y cells, thereby reducing intracellular levels of polyQ aggregates and their concomitant cytotoxicity. Treatment of cells wi...

The aim of this study was to describe pacing profiles used by senior men competing in the World Cross Country Championships. Lap times were collated for 1273 competitors across 10 races. Each individual's lap times were expressed as a percentage of the eventual winner's lap times, and athletes were grouped according to finishing position. Most athletes started the race by following the pace set...

β-lapachone (β-lap) is a naturally occurring quinone obtained from the bark of lapacho tree (Tabebuia avellanedae) with anti-proliferative properties against various cancers. The present study investigated the cell proliferation and apoptosis effect of β-lap on two oral squamous cell carcinoma lines (OSCCs). We carried out a series of 3-(4,5-dimethylthiazol2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-...

BACKGROUND This meta-analysis compared laparoscopic surgery (LAP) and open resection (OPEN) for the treatment of gastric gastrointestinal stromal tumors (GISTs) with regard to feasibility and safety. METHODS We searched PubMed, Embase, and Web of Science for studies published before March 2016 comparing the LAP and OPEN procedures for GISTs. RevMan 5.1 software was used for the meta-analysis....

BACKGROUND Non-alcoholic fatty liver disease (NAFLD), recognized as the liver manifestation of metabolic syndrome, is highly prevalent in the general population. Recent studies suggest that lipid accumulation product is significantly associated with metabolic abnormalities. The aim of this study was to assess the accuracy of lipid accumulation product (LAP) as an effective screening tool for di...

Lamp 1 and lysosomal acid phosphatase (LAP) are lysosomal membrane proteins that harbour a tyrosine-based sorting motif within their short cytoplasmic tails. Lamp 1 is delivered from the trans-Golgi network (TGN) via endosomes directly to lysosomes bypassing the plasma membrane, whereas LAP is indirectly transported to lysosomes and recycles between endosomes and the plasma membrane before bein...