BACKGROUND Gain of 3q26 is frequently observed in squamous cell carcinomas of mucosal origin, including those originating in the head and neck region. The human telomerase RNA component (hTERC) gene, which is located on chromosome 3q26, encodes for an RNA subunit of telomerase that maintains the length of telomeres through cellular divisions, and is activated in malignant diseases. The present ...

introduction: laryngeal dysfunction may be divided into three categories; organic, neurologic and functional disorders. dysphonia and hoarseness are the most common symptoms and, in some cases, the only signs of laryngeal dysfunction. in differential diagnosis of any type of chronic hoarseness, a neoplastic process must be considered and, thus continuous light video laryngoscopy can provide imp...

Intoduction: Dysphonia is the main symptom of lesions that affect the larynx. Many of those require surgical treatment. Vocal cord lesions are the most common and the most prevalent indication for laryngeal microsurgery. Aim: To conduct a study of laryngeal lesions and their management by microlaryngoscopy. Materials and methods:The main objective being to highlight the importance of microlaryn...

At their earliest stage, pathologic lesions of the laryngeal epithelium are macroscopically invisible. Ideally, these lesions should be detected before their clinical manifestations appear so that prompt management can be initiated. However, most diagnostic modalities are unable to detect early premalignant lesions. We conducted a retrospective study of the use of contact endoscopy in analyzing...

Introduction The role of the speech-language pathology in the multiprofessional team dealing with laryngology and the voice has been recognized for a long time. Scientific studies in this field recommend therapies for laryngeal microsurgeries; few of the studies, however, effectively evaluate the result of postoperative speech therapy. Objective To compare speech therapy evaluation and treatmen...

OBJECTIVE To determine whether levels of PH-20, a hyaluronidase similar to that found in human sperm, are elevated in laryngeal cancer tissue. DESIGN In this case-control study. reverse transcription polymerase chain reaction was used to measure levels of PH-20 messenger RNA in tissue taken from laryngectomy specimens. SETTING A university medical center. PATIENTS We compared tissue sampl...

OBJECTIVES/HYPOTHESIS Office-based biopsy (OBB) is widely used to diagnose suspicious laryngeal lesions. However, its routine use is still controversial and the algorithm for clinical strategy is not concrete. We tried to evaluate the accuracy of OBB as a diagnostic tool for laryngeal malignancy. METHODS Medical data of 581 patients undergoing OBB were reviewed. Diagnostic values of OBB were ...

Chondrosarcoma, a sub mucosal hard, slow growing and local aggressive tumor, is the most frequent mesenchymal neoplasm of the larynx. Diagnosis is supported both by clinical appearance and radiological evaluation, even because a biopsy is not always easy to obtain, due to its hardness. Laryngeal chondrosarcomas are histologically differentiated as low-, intermediateand high-grade lesions and to...

Automated classification of laryngeal lesions using optical coherence tomography data can be helpful in making a faster and safer diagnosis. A change in the epithelial layer thickness seems to be an effective indicator for laryngeal cancer and its precursors. Lesions with different grades of malignancy were scanned with a time domain OCT system during microlaryngoscopy. Every diagnosis was conf...

Benign laryngeal disorders result in dysphonia because of effects on glottic closure and the vibratory characteristics of the true vocal fold. Treatment is initially directed at reversing medical conditions and patterns of abuse with surgery reserved for unresolving lesions resulting in troublesome dysphonia. Benign lesions that require surgery are excised as precisely as possible sparing overl...