LCH: Langerhans cell histiocytosis INTRODUCTION Langerhans cell histiocytosis (LCH) identifies a spectrum of disorders that are classified according to the organs involved (singleor multi-organ disease) and the presence or absence of organ failure. Patients younger than 2 years with a multisystem disease have a significantly higher mortality rate than older children. Nail involvement in LCH is ...

Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is an uncommon hematological disorder affecting infants and young children. It is the condition characterized by uncontrolled stimulation and proliferation of normal antigen presenting cells, Langerhans cells. Because of its relatively low incidence, limited data are available regarding the epidemiology of LCH, with estim...

As a polypoid form of capillary hemangioma, lobular capillary hemangioma (LCH) most commonly occurs on the cutaneous and mucosal surfaces and is frequently benign in children. Tracheal LCH is a rare benign tumor in adults, with hemoptysis being one of the most serious forms of presentation. A definite diagnosis of LCH depends on its histopathology. In clinical practice, however, radiological ch...

Capillary hemangioma also known as lobular capillary hemangioma (LCH) or pyogenic granuloma is a benign, vascular lesion of unknown origin, composed of blood vessels and are probably developmental rather than neoplastic in origin. They usually affect skin and mucous membranes of the oral cavity and rarely nasal mucosa. LCH bleeds on manipulations due to high vascularity. Microtraumas and hormon...

BACKGROUND Crusted Norwegian scabies is a rare hyperkeratotic variant of scabies infestation. We report herein a case of crusted scabies in a woman with underlying Langerhans cell histiocytosis (LCH). OBSERVATIONS A 49-year-old woman with LCH was hospitalized owing to marked thrombocytopenia. Her hyperkeratotic skin eruption was thought to be secondary to LCH because several years earlier, sh...

We presented the abdominal computed tomography (CT) findings of four cases of Langerhans’ cell histiocytosis (LCH) in children (age ranged from 11 month-old to 2 year-old, two boys and two girls), who clinically had either fever, skin rash, hepatosplenomegaly, persistent jaundice, elevated liver enzymes, or lymphadenopathy. CT showed variable findings, including: hepatomegaly, splenomegaly, liv...

Langerhans cell histiocytosis (LCH) is characterized by uncontrolled proliferation of Langerhans cells accompanying eosinophils. It often attacks children under 10 years of age. LCH in identical twins is very rare and its prognosis is different. Here we report identical-twin sisters with LCH. Computed tomography (CT) revealed osteolytic change in each twin's skull, and the elder exhibited poor ...

BACKGROUND The clinical presentation and course of Langerhans cell histiocytosis (LCH) are variable, ranging from an isolated, spontaneously remitting bone lesion to multisystem disease with risk organ involvement. Treatment of LCH ranges from a wait-and-see attitude to intensive multidrug therapy and, in some cases, bone marrow transplantation. It is necessary to develop an objective score for...

In pediatric and adolescent patients, the most common causes for a thickened pituitary stalk with central diabetes insipidus are germ cell tumors, lymphocytic infundibuloneurohypophysitis (LIN), and Langerhans cell histiocytosis (LCH). We describe here a 13-year-old girl who had an abrupt onset of polyuria and polydipsia. Magnetic resonance imaging of the brain revealed thickening of the pituit...