The theory of light scattering indicates that aggregation of the crystalline lens proteins can produce opacity. Furthermore, it is known that calcium increase? in the cataractous lens. We have, therefore, investigated the effectiveness of calcium ion in producmg aggregates of the soluble proteins of the bovine lens. The experimental restdts show: (1) CaCU produce's aggregates of the soluble pro...

AIM To investigate the examination of lens opacities in routine ophthalmic clinical practice. METHOD A questionnaire survey was mailed to 703 consultant ophthalmologists in the UK. The surgeons were asked which lens feature(s) they assessed in their clinics when deciding whether to offer cataract surgery. RESULTS 489 replies were received. A broad range of lens opacities was assessed, with ...

Freshly isolated rabbit lenses were incubated in anosmolar culture media to study the effects of osmotic shock on lens transparency and protein synthesis. The rate of protein synthesis was measured using three markers, namely alpha-crystallin, a water soluble protein, vimentin, a cytoskeletal protein and MP-26, an intrinsic membrane protein. It was found that only when lenses were cultured in a...

PURPOSE The Rop (radial opacity) mutation, which was recovered in a mutagenicity screen after paternal treatment with procarbazine, was analyzed to determine phenotype, chromosomal localization, candidate genes, and molecular lesion. METHODS Native lenses were photographed under a dissecting microscope. Histologic sections of the eye were made according to standard procedures. Fine mapping of...

Oxidative stress has an important role in the degradation, oxidation, cross‑linking and aggregation of lens proteins, and can trigger lens epithelial cell apoptosis. To investigate the protective effect of chlorogenic acid (CGA) against hydrogen peroxide (H2O2)‑induced oxidative stress, human lens epithelial cells (hLECs) were exposed to various concentrations of H2O2 in the presence and absenc...

OBJECTIVE To evaluate the results of thermotherapy for retinoblastoma. DESIGN Prospective, nonrandomized analysis of the treatment method. PARTICIPANTS A total of 188 retinoblastomas in 80 eyes of 58 patients who were treated with thermotherapy. MAIN OUTCOME MEASURES Tumor response and ocular adverse effects. RESULTS Of 188 retinoblastomas treated with thermotherapy, mean tumor base was...

A case of a Brazilian Terrier puppy presenting diabetic lens opacity that restored transparency after insulin therapy and control of blood glucose levels is reported. This entity has been rarely reported in human beings and has not been reported in dogs before. The rapid glycemic control may have been responsible for the transparency recovery.