Dermal papilla (DP) is the key mesenchymal niche cell type, that regulates cyclic regeneration of hair follicles by orchestrating paracrine signaling crosstalk with epithelial progenitors. We discovered leptin receptor (Lepr) a robust marker gene adult DP fibroblasts in mice and constitutive Cre inducible CreER genetic tools, whose activity follows expression Lepr isoform B, can efficiently tar...

3. NUNN, P. P. and McADANI, R. I'. W. J. Mycobacte-^5. rial infections and AIDS. Br. Med. Bull. 44 (1988) 801-803. 4. 01.ivAius, L. M., PizzARID.I.o, G. E. A., BENETUCCI,^6. J. and FARINA, M. 11. Lepromatous leprosy with II1V infection. Int. J. Lepr. 62 (1994) 295-296. VREEBURG, A. E. M. Clinical observations on leprosy patients with HIV-1 inlection in Zambia. Lepr. Rev. 63 (1992) 134-140. WoRi...

A double-volute molten salt pump with two outlet pipes is proposed based on the original model. numerical approach coupling finite element analysis and computational fluid dynamics (CFD) implemented to investigate operational stability energy performance of centrifugal pumps for high-temperature salt. The entropy production single-volute investigated. effects volute structures mechanical behavi...

Type 1 diabetes mellitus (T1DM) is still associated with increased risk for severe maternal and fetal complications but their pathomechanism remains unclear. We investigated into possible role of placental leptin (LEP) and its receptor gene (LEPR) in T1DM pregnancies. Fourty nine pregnant women with T1DM and singleton pregnancy were enrolled into the study. Control group consisted of 15 healthy...

The vagal afferent pathway senses hormones released from the gut in response to nutritional cues and relays these signals to the brain. We tested the hypothesis that leptin resistance in vagal afferent neurons (VAN) is responsible for the onset of hyperphagia by developing a novel conditional knockout mouse to delete leptin receptor selectively in sensory neurons (Nav1.8/LepR (fl/fl) mice). Cho...

BACKGROUND Recessive mutations in the leptin receptor (LEPR) are a rare cause of hyperphagia and severe early-onset obesity. To date, the phenotype has only been described in 25 obese children, some of whom also had altered immune function, hypogonadotropic hypogonadism, reduced growth hormone secretion, hypothalamic hypothyroidism or reduced adult height. We provide a detailed description of t...

OBJECTIVE The purpose of this study was to investigate the impact of the interactions among CX3CL1 (rs170364 and rs614230), LEPR (rs6700896), and IL-6 (rs2066992) polymorphisms on the risk of coronary artery disease (CAD) in Chinese Han population. METHODS 120 CAD patients and 109 healthy controls were enrolled in the study. Polymerase chain reaction (PCR) and direct sequencing methods were u...

Recently, we identified in normally type 1 diabetes-prone NOD/LtJ mice a spontaneous new leptin receptor (LEPR) mutation (designated Lepr(db-5J)) producing juvenile obesity, hyperglycemia, hyperinsulinemia, and hyperleptinemia. This early type 2 diabetes syndrome suppressed intra-islet insulitis and permitted spontaneous diabetes remission. No significant differences in plasma corticosterone, s...

Leptin and leptin receptor genes are considered as production traits markers in dairy or beef cattle. The aim of this study was to verify the associations of polymorphisms in bovine LEP and LEPR genes with production and reproduction traits in Slovak Spotted and Pinzgau cows. Long-life production was evaluated: milk, protein, and fat yield and reproduction traits: age at first calving, calving ...

conclusions in general, our study suggests that the association between lep/lepr and ghrl/ghsr with overweight/obesity and the related metabolic disturbances is inconclusive. these results may be due to unidentified gene-environment interactions. more investigations are needed to further clarify this association. results the most prevalent leptin/leptin receptor genes (lep/lepr) and ghrelin/ghr...