OBJECTIVE Clopidogrel inhibits platelet aggregation by blockade of platelet adenosine diphosphate (ADP) P2Y12 receptor. Leptin is the obesity gene product, and its serum level increases with obesity. Platelets have leptin receptors on their surfaces. Hyperleptinemia may induce ADP-mediated platelet aggregation. It has been proposed that clopidogrel effect could be diminished with high serum lep...

Energy balance in mammals is modulated by peripheral signals that inform the brain about the magnitude of fat stores, the amount of food in the gastrointestinal tract, and the level of nutrients such as glucose in the circulation. Among these, insulin and leptin are considered adiposity signals involved in the long-term maintenance of fat stores. Here we review the mechanisms of action of lepti...

evidence acquisition elevated serum leptin levels are regarded as an established marker of obesity. it is also reported that obese asthmatic patients have maximum serum leptin levels compared to other groups such as non-obese asthmatics, and normal obese and non obese subjects without asthma. in addition to having an appetite suppressing effect, leptin also regulates certain acute-phase protein...

Background: Obesity and insulin resistance refer to a clustering of various medical conditions, with a number of pathological components that contribute to the development of diabetes and cardiovascular disease. Some studies have shown that free testosterone levels are low in obese men and are inversely correlated with the degree of obesity. In addition, leptin levels increases with obesity tha...

The purpose of this study was to determine whether leptin induces leptin resistance by examining the temporal attenuation of the anorexic and energy expenditure responses to leptin. We administered recombinant adeno-associated virus encoding rat leptin cDNA or control viral vector into mildly obese rats for 138 d and compared these results with those from pair-fed rats. We measured food consump...

Background. Adipose tissue secrets various hormones in body such as adiponectin which has close relationship with controlling weight. Objectives. Therefore, the present article determines movement pattern effect of resistance training on adiponectin, in young men. Methods. 40 male untrained students in 23.8±2.66 years old and weight of 67.43±4.96 kg were randomly selected,...

LEPTIN WAS CLONED IN 1994 and shown to be secreted from adipocytes (5). This and subsequent studies demonstrated that leptin is made and secreted in proportion to the fat content of individual adipocytes (4). Under normal physiological conditions, the concentration of circulating leptin is inversely related to body fat, or energy, content (2). It is transported past the bloodbrain barrier and a...

INTRODUCTION: Leptin is a hormone resulting from the obesity gene which could be important in the pathogenesis of the insulin. Only limited data concerning the interaction of insulin, glucose tolerance and free leptin are available and no data exist on the potential influence of free vs. bound circulating leptin. We, therefore, studied percentage of free to total leptin in diabetic patients. ...