Siberian hamsters decreased body weight by 30% during 18 wk in short day (SD) vs. long day (LD) controls. Subsequent imposed food deprivation (FD; 24 h) caused a further 10% decrease. In the hypothalamic arcuate nucleus (ARC), SDs reduced proopiomelanocortin (POMC) gene expression and agouti-related protein (AGRP) mRNA was elevated, changes that summate to reduced catabolic drive through the me...

During the lifetime of an adult organism, stem cells face extrinsic and intrinsic aging. Mesenchymal stem cells (MSC) can be expanded in culture, and the proliferation potential of individual cell isolates before growing senescent appear to be dependent on fitness and age of the donor, respectively. To date no molecular markers are available, which specifically reflect the degree of cellular ag...

Neurons that express pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) in the arcuate nucleus of the hypothalamus suppress feeding and increase energy expenditure in response to circulating adiposity signals such as leptin. Alterations in gene expression may lead to long term modification of this circuit and alterations in body weight. Therefore, understanding...

Abstract Pro-opiomelanocortin (POMC) neurons in the hypothalamus play a role both control of metabolic state and sexual behavior. Along with fast neurotransmitters glutamate and/or GABA, POMC secrete cocaine- amphetamine-regulated transcript (CART) products gene, including β-endorphin α-melanocortin stimulating hormone (α-MSH). Published data from our lab demonstrate lack interest male mice whe...

The use of probiotics has been recently considered a novel therapeutic strategy to prevent pathologies such as obesity; however, the specific mechanisms action by which exert their beneficial effects on metabolic health remain unclear. aim present study was investigate short-term probiotic Lactobacillus rhamnosus supplementation (PROB) appetite regulation, growth-related markers, and microbiota...

background: leptin is a protein product of obesity gene and is synthesized mainly by adipose tissue. objective: the aim of this study was to determine maternal and neonatal serum leptin levels in term preeclamptic and normal pregnancies. materials and methods: this cross sectional study was performed on 37 preeclamptic and 40 normotensive term pregnant women without other disease. serum level o...

Abstract Leptin plays a major role in the regulation of energy intake and expenditure, triggering effects on several tissues, such as hypothalamic-pituitary-thyroid axis. The reported leptin thyroid are controversial, being mainly explored during imbalance. Therefore, aim this study was to evaluate function rats fed ad libitum distinguishing direct responses from those mediated by leptin-depend...

Background The relationship between metabolism and reproduction has been always considered as an important topic in female endocrinology. It seems that leptin is one of the involved factors in infertility. Leptin, in addition to regulating body weight plays an important role in regulation of endocrine, reproductive and immune systems. The aim of this stduy is to compare serum and follicular flu...

background â to investigate any possible relationship between serum leptin level and h. pylori infection in dyspeptic iranian adults. methods a total of 153 dyspeptic patients referring to  firoozgar hospital for esophagogastroduodenoscopy were enrolled in the study. serum leptin level was measured before endoscopy, after overnight fasting. two biopsy specimens were taken from antrum for each p...