A preliminary study of the characteristics of the leukemoid response to transplantable A-280 tumor in BALB/c and B6D2 FI mice is presented. A direct correlation between the magnitude of leukemoid response and the duration of tumor implant was noted. Liver, kidney, spleen, and adrenals of leukemoid tumor-bearing animals showed an increase in weight which was correlated with myelogenous cellular ...

Intracellular biochemical reactions exhibit a rich dynamical phenomenology which cannot be explained within the framework of mean-field rate equations and additive noise. Here, we show that the presence of metastable states and radically different time scales are general features of a broad class of autocatalytic reaction networks, and that this fact may be exploited to gain analytical results....

The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over las...