نتایج جستجو برای: leukocyte mycobacterium defect

تعداد نتایج: 173782  

Journal: :Infection and immunity 2001
S H El-Etr L Yan J D Cirillo

Mycobacterium marinum, a relatively rapid-growing fish and human pathogen, has become an important model for the investigation of mycobacterial pathogenesis. M. marinum is closely related to the Mycobacterium tuberculosis complex and causes a disease in fish and amphibians with pathology similar to tuberculosis. We have developed an in vitro model for the study of M. marinum virulence mechanism...

Journal: :Journal of clinical microbiology 1989
R H Eng E Bishburg S M Smith A Mangia

Thirty acquired immunodeficiency syndrome patients with mycobacterial bacteremia documented by Du Pont Isolator (Du Pont Co., Wilmington, Del.) blood cultures underwent microscopic examination of buffy coat blood smears. Of 30 patients, 14 were culture positive for Mycobacterium avium-Mycobacterium intracellulare complex and 1 was positive for M. tuberculosis. Of 15 culture-positive patients, 1...

Journal: :Infection and immunity 2003
Todd M Lasco Toshiko Yamamoto Teizo Yoshimura Shannon Sedberry Allen Lynne Cassone David N McMurray

In this study, we focused on three leukocyte-rich guinea pig cell populations, bronchoalveolar lavage (BAL) cells, resident peritoneal cells (PC), and splenocytes (SPC). BAL cells, SPC, and PC were stimulated either with live attenuated Mycobacterium tuberculosis H37Ra or with live or heat-killed virulent M. tuberculosis H37Rv (multiplicity of infection of 1:100). Each cell population was deter...

تاج‌الدین, الهه, حیدری, فضه, فرنیا, پریسا, مجد, احمد, مسجدی, محمدرضا, نوروزی, جمیله, ولایتی, علی‌اکبر,

Background and Objective: Identification of atypical mycobacterium (Non tuberculosis Mycobacterium NTM) is important because of the worldwide propagation of these organisms. Recently, molecular studies have identified the specific loci for mycobacterium species by DNA - finger printing methods, but these methods are time-consuming and expensive. In this study, in addition to hsp65 PCR-RFLP meth...

Journal: :The Journal of biological chemistry 1989
T K Kishimoto K O'Conner T A Springer

Leukocyte adhesion deficiency (LAD) is a heritable deficiency of the LFA-1, Mac-1, p150,95 family of leukocyte alpha beta heterodimers (the leukocyte integrins). We have studied the defect in patients who synthesize an aberrantly small form of the beta subunit common to all three proteins. S1 nuclease protection showed the presence of a 90-nucleotide mismatch in RNA from patients and relatives,...

Journal: :The Journal of Cell Biology 1973
Michael S. Jensen Dorothy F. Bainton

Although previous workers have established that the pH of the phagocytic vacuole of the polymorphonuclear (PMN) leukocyte changes from neutral to acid, the time course of conversion has not been investigated. The present experiments were initiated to study pH changes immediately after phagocytosis. Peritoneal exudates were induced in rats; 4 h later, yeast stained with pH indicators was injecte...

2017
Yunmei Wang Huiyun Gao Can Shi Paul W. Erhardt Alexander Pavlovsky Dmitry A. Soloviev Kamila Bledzka Valentin Ustinov Liang Zhu Jun Qin Adam D. Munday Jose Lopez Edward Plow Daniel I. Simon

Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 in thrombosis is undefined. Here we report that mice with Mac-1 deficiency (Mac...

Journal: :Blood 2010
Laura Tassone Daniele Moratto William Vermi Maria De Francesco Lucia D Notarangelo Fulvio Porta Vassilios Lougaris Fabio Facchetti Alessandro Plebani Raffaele Badolato

Warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome is a genetic disease that is caused by heterozygous mutations of the CXCR4 gene. These mutations confer an increased leukocyte response to the CXCR4-ligand CXCL12, resulting in abnormal homeostasis of many leukocyte types, including neutrophils and lymphocytes. Analysis of the myeloid and plasmacytoid dendritic cell blood c...

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