conclusions we observed no significant differences between the two groups in lipid and carbohydrate metabolism, except for hdl-c. considering the importance of overweight and obese women’s health, studies with longer follow-up periods are recommended in this respect. results the differences in lipid and carbohydrate parameters were not significant between the two groups, except for hdl-c (adjus...

implantable contraceptive is likely to be a promising new option for fertility control, as we have entered the twenty-first century and the world’s population grows by one billion people in a single decade. the main objective of this study was to develop a subdermal implant for levonorgestrol (a synthetic progestin from 19-norandrostanes) using a high molecular weight biodegradable polymer , i....

OBJECTIVE To assess the efficacy of tranexamic acid or mefenamic acid in the management of the initial "nuisance" bleeding or spotting in the period immediately after placement of the levonorgestrel-releasing intrauterine system. METHODS Women were randomized after levonorgestrel-releasing intrauterine system placement to oral tranexamic acid (500 mg), mefenamic acid (500 mg), or placebo thre...

Contraception: The Effective and Appropriate Use of Longacting Reversible Contraception. London, UK: RCOG Press, October 2005 http://www.nice.org.uk/pdf/ CG030fullguideline.pdf [Accessed 7 February 2006]. 2 Jarvela I, Tekay A, Jouppila P. The effect of a levonorgestrel-releasing intrauterine system on uterine artery blood flow, hormone concentrations and ovarian cyst formation in fertile women....

OBJECTIVE To assess the risk of pulmonary embolism, ischaemic stroke, and myocardial infarction associated with combined oral contraceptives according to dose of oestrogen (ethinylestradiol) and progestogen. DESIGN Observational cohort study. SETTING Data from the French national health insurance database linked with data from the French national hospital discharge database. PARTICIPANTS ...

BACKGROUND According to 3 randomized trials, the levonorgestrel-releasing intrauterine system significantly reduced recurrent endometriosis-related pelvic pain at postoperative year 1. Only a few studies have evaluated the long-term effectiveness of the device for preventing endometrioma recurrence, and the effects of a levonorgestrel-releasing intrauterine system as a maintenance therapy remai...

OBJECTIVE To compare the effectiveness of nonsurgical abnormal uterine bleeding treatments for bleeding control, quality of life (QOL), pain, sexual health, patient satisfaction, additional treatments needed, and adverse events. DATA SOURCES MEDLINE, Cochrane databases, and Clinicaltrials.gov were searched from inception to May 2012. We included randomized controlled trials of nonsurgical tre...

©FSRH J Fam Plann Reprod Health Care 2009: 35(4) Background Two studies recently published in the British Medical Journal, a retrospective cohort study using information from the Danish registries1 and the MEGA case-control study for which cases were identified via specialised anticoagulation clinics in The Netherlands,2 revisit the question of whether so-called ‘third generation’ combined oral...