BACKGROUND Suppressive therapy with levothyroxine for reducing the size of thyroid nodules has not been really accepted. The purpose of this study was to assess the effect of levothyroxine on the size of benign thyroid nodules. METHODS Forty patients with confirmed benign nodule were randomly divided into two groups. Group I received 50g/day levothyroxine for six months but group II did not t...

Subclinical hypothyroidism (SCH) is a common problem in pediatric population, and the natural history of SCH varies depending on its etiology. Whether Hashimoto's thyroiditis (HT) negatively affects the natural course of SCH was investigated in pediatric patients without concomitant diseases. Predictors for levothyroxine medication were also evaluated. Medical records of 109 children with SCH (...

Introduction: Some studies indicate changes in the level of thyroid hormones in addicted people. Also, there are some reports concerning the modulation of hypothalamus-hypophysis-thyroid axis in the context of morphine addiction. In the present study, the effects of thyroid gland activation via the acute and chronic administration of levothyroxine on morphine withdrawal syndrome were investi...

Objectives: The aim of the present study was to investigate the misuse of levothyroxine treatment in patients with hypothyroidism. Methods: Patients who received levothyroxine treatment were included in the study. Age, gender, duration of medication use, Thyrotropin (TSH) level, regular use of medication, time and manner of taking medication, drug storage conditions and use of additional medica...

OBJECTIVE There is controversy as to whether hypothyroidism increases cardiovascular risk. The effect of levothyroxine on the cardiovascular risk profile is also unclear. Recent studies suggest that there is evidence of inflammation and endothelial dysfunction in hypothyroidism. Soluble CD40 ligand (sCD40L) is a protein expressed mainly by activated platelets which have been found to be associa...

Long-standing untreated primary hypothyroidism is an uncommon cause of praecocious puberty. The hypothyroidism, incomplete sexual maturation, galactorrhoea, and pituitary enlargement are reversed or corrected by levothyroxine therapy within a few months. We report a young girl with juvenile hypothyroidism who presented with early onset of menarche with failure of growth who was treated successf...

Hypothyroidism is due to the primary disease of the thyroid or secondary to hypothalamicpituitary disease [1]. Primary hypothyroidism is the most common endocrine disorder throughout the world. Traditionally we have been using levothyroxine in the treatment of hypothyroidism. However, there have been reports of persisting symptoms of hypothyroidism in 5-10% of levothyroxine treated hypothyroid ...

BACKGROUND We studied quality of life (QOL), anxiety, and depression in patients with differentiated thyroid cancer (DTC) either during treatment with levothyroxine or during withdrawal from levothyroxine when whole-body scanning (WBS) needed to be performed. METHODS DTC patients projected to undergo WBS were included in the study. They were studied at two time-points - the day before levothy...

introduction: hypothyroidism is diagnosed by elevated thyroid stimulating hormone (tsh) and normal or decreased serum levels of t4 or t3, and is associated with a wide range of m etabolic abnormalities, including anemia. this clinical study aimed to assess the improvement of anemia in patients with primary hypothyroidism following administration of levothyroxine in iranian population. materials...

Many causes of malabsorption of levothyroxine in patients with hypothyroidism have been thoroughly described in literature. Pseudomalabsorption, poor compliance of the patient with the therapy regime, is the most common cause of failure of levothyroxine therapy. Pseudomalabsorption is characterised by a deficient diagnostic process, patient denial and difficulties in treatment. The present arti...