OBJECTIVE Osteocalcin is a well-known marker of bone formation. Recently, mice lacking osteocalcin or its receptor were reported to be subfertile with low testosterone and high luteinizing hormone concentrations. In parallel, in humans, a loss-of-function mutation of the osteocalcin receptor was associated with hypergonadotropic hypogonadism. This suggests that osteocalcin is necessary for norm...

During ovarian follicle growth, precise regulation of the onset of androgen production by ovarian theca-interstitial cells (TIC) is necessary for maintaining follicle viability. Thus, temporary suppression of TIC androgen production in preantral follicles is the key to promoting follicle development. Evidence indicates that this process is coordinated via intraovarian growth factors. Hepatocyte...

Let L be a second order elliptic differential operator on a Riemannian manifold E with no zero order terms. We say that a function h is L-harmonic if Lh = 0. Every positive L-harmonic function has a unique representation

[Purpose] Superficial heat treatment is one of the most widely used physical therapies for osteoarthritis (OA). We clinically evaluated the effects of local heat treatment and exercise therapy for knee OA, and evaluated the articular cartilage using magnetic resonance imaging (MRI) T2 mapping. [Subjects and Methods] Eighteen females aged 50-69 (59.5 ± 8.5 years, mean ± SD) years diagnosed with ...

BACKGROUND The competence for embryonic development after IVF is low in the yak, therefore, we investigated the effects of supplementation of FSH, LH and the proteasome inhibitor MG132 in IVM media on yak oocyte competence for development after IVF. METHODS In Experiment 1, yak cumulus-oocyte complexes (COCs) were in vitro matured (IVM) in TCM-199 with 20% fetal calf serum (FCS), 1 microg/mL ...

Luteinizing hormone (LH) receptor sites and in vitro testosterone production in response to human chorionic gonadotropin (hCG) stimulation (Leydig cell responsiveness) were studied in two distinct populations of Leydig cells after different modes of in vivo gonadotropin treatments. Dispersed cells from decapsulated rat testes were purified and separated into two distinct populations of Leydig c...

Large and small cells were isolated from porcine corpora lutea (CL) on d 10, 15 or 18 of the estrous cycle. They were incubated 13 to 16 h in cholesterol- and serum-free media and then supplied with 0, 10, 50 or 100 micrograms of either porcine low density lipoprotein (LDL) or porcine high density lipoprotein (HDL). Each dose was supplemented with 0, 10, 50 or 100 ng of porcine LH. Media proges...

Atrazine (ATR) blunts the hormone-induced luteinizing hormone (LH) surge, when administered by gavage (50-100 mg/kg/day for 4 days), in ovariectomized rats. In this study, we determined if comparable doses delivered either by gavage (bolus dose) or distributed in diet would reduce the LH surge and subsequently affect fertility in the intact female rat. ATR was administered daily to intact femal...

Abstract With Mapping Nearby Galaxies at APO integral field spectroscopy, we present a resolved analysis of star formation for 29 jellyfish galaxies in nearby clusters, identified from radio continuum imaging taken by the Low Frequency Array. Simulations predict enhanced on “leading half” (LH) undergoing ram pressure stripping, and this work report observational evidence elevated formation. The...

BACKGROUND Leptin, which is the product of the obese gene, is believed to play important roles in pubertal development and reproductive function in females. In a study using adult male rats, it was found that leptin stimulated secretion of gonadotropin from the pituitary in a dose-related manner. However, there has been no such study in female rats. OBJECTIVE To investigate the effects of lep...