BACKGROUND Postoperative pain management is important for preventing perioperative complications. The authors examined the effectiveness of controlled-release lidocaine for sciatic nerve block in a rat model of postoperative pain. METHODS The authors created a novel slow-release lidocaine sheet (SRLS) with polylactic-coglycolic acid. In male Sprague-Dawley rats (postoperative pain model), the...

BACKGROUND AND OBJECTIVE Intravenous regional anesthesia (IVRA) for upper limb surgeries with traditional high dose of lidocaine can lead to life threatening side effects. In order to avoid these potential life threatening side effects, many modified techniques of IVRA have been attempted by using a low dose of lidocaine, muscle relaxant and opioid. METHOD The present study is carried out in ...

Local anesthetics are commonly used for pain relief by regional nerve blocking. In this study, we fabricated solvent-free biodegradable pellets to extend the duration of lidocaine release without any significant local or systemic toxicity levels. To manufacture the pellets, poly[(d,l)-lactide-co-glycolide] (PLGA) was first pre-mixed with lidocaine powder into different ratios. The powder mixtur...

Lidocaine has not been associated with cancer in humans despite 8 decades of therapeutic use. Its metabolite, 2,6-xylidine, is a rat carcinogen, believed to induce genotoxicity via N-hydroxylation and DNA adduct formation, non-threshold mechanism action. To better understand this dichotomy, we review literature pertaining metabolic activation identifying that it appears resistant instead metabo...

Clinical effectiveness of the double-blind administration of 1 and 2% lidocaine solutions was evaluated for restorative and surgical procedures on primary molars of children 4.5 to 10.5 years old. This effectiveness was measured by changes in the child's heart rate, the child's self report of pain, and the operator's assessment of the anesthesia's effectiveness. Although the incidence of anesth...

An ideal local anesthetic should act swiftly and be efficacious without causing discomfort or toxicity. Buffered is useful when it comes to limiting toxicity because of the reduced volume that needed decreased time takes effective compared with other conventional means. anesthesia uses sodium bicarbonate mixed into lidocaine prior injection neutralize acid. All patients were explicated about st...

Purpose: The effectiveness of daily or weekly instillation of non-alkalinized lidocaine for patients suffering interstitial cystitis and/or bladder pain syndrome was evaluated retrospectively. Patients and Methods: Five female patients (40 71 years old) diagnosed as interstitial cystitis by cystoscopic findings and a 68-year-old bladder pain syndrome patient were enrolled. All patients, having ...

PURPOSE To examine whether inhibition of P-glycoprotein (P-gp) activity by quinidine affects the central nervous system toxicity of lidocaine and racemic bupivacaine (bupivacaine). METHODS Forty male Sprague-Dawley rats were randomly divided into four groups (n = 10). Fifteen minutes following administration of 15 mg x kg(-1) of quinidine (QL and QB groups) or saline (L and B groups), lidocai...

anesthetic agent as well as lidocaine, bupivacaine and mepivacaine (Fig. 1). Unlike bupivacaine and mepivacaine, which are racemic mixtures of the enantiomers containing equal proportion of the (S) and (R) forms, ropivacaine is exclusively the (S)-enantiomer. Since the (R)-enantiomer in the racemic aminoamide has known to be toxic, ropivacaine potentially provides lower toxicity on heart and ce...