objective(s): multiple sclerosis (ms) is an autoimmune demyelinating disease of the central nervous system (cns) with unknown etiology. various genetics and environmental factors contribute to the pathogenesis of the disease. the interleukin-7 receptor alpha chain (il-7ra) was identified as the first non-major histocompatibility complex (non-mhc) ms susceptibility locus. in this study we are tr...

Eosinophils are implicated prominently in allergic diseases and the host response to parasitic infections. Eosinophils may be activated in vitro by diverse classes of agonists such as immunoglobulins, lipid mediators, and cytokines. The leukocyte Ig-like receptors (LIRs) comprise a family of inhibitory and activating cell-surface receptors. Inhibitory LIRs down-regulate cellular responses throu...

Toll-like receptors (TLRs) are a class of pattern recognition receptors that play a bridging role in innate immunity and adaptive immunity. The activated TLRs not only induce inflammatory responses, but also elicit the development of antigen specific immunity. TLR7, a member of TLR family, is an intracellular receptor expressed on the membrane of endosomes. TLR7 can be triggered not only by ssR...