نتایج جستجو برای: linear no threshold theory lnt

تعداد نتایج: 4311541  

Journal: :Dose-response : a publication of International Hormesis Society 2012
Mohan Doss

The current radiation safety paradigm using the linear no-threshold (LNT) model is based on the premise that even the smallest amount of radiation may cause mutations increasing the risk of cancer. Autopsy studies have shown that the presence of cancer cells is not a decisive factor in the occurrence of clinical cancer. On the other hand, suppression of immune system more than doubles the cance...

Journal: :Dose-response : a publication of International Hormesis Society 2011
Bobby R Scott

Residential radon has been found to be associated with lung cancer in epidemiological/ecological studies and the researchers have inappropriately concluded that residential radon causes lung cancer. Their conclusion relates to the linear-no-threshold (LNT) hypothesis-based, risk-assessment paradigm; however, the LNT hypothesis has been invalidated in numerous studies. It is shown in this paper ...

2013
N Pace L Ricci

Methods Starting point of the analysis is the Linear Non Threshold (LNT) assumption for radiation stochastic effect [1]: for effective doses (E) below 100 mSv, the probability of future stochastic damage is linearly related to E. This allows to add E from different sources to calculate a cumulative risk of health detriment. Data coming from literature were gathered to determine the average E de...

2013
Sergei V. Jargin

Asbestos-related health risks have been evaluated on the basis of past experience, when occupational exposures were much higher; while the linear no-threshold (LNT) approach has usually been applied. However, applicability of the LNT dose-response pattern to low levels of asbestos exposure has never been proven. Asbestos-related research has been influenced by vested interests and biases. Furth...

2017
Edward J. Calabrese

The historical foundations of cancer risk assessment were based on the discovery of X-ray-induced gene mutations by Hermann J. Muller, its transformation into the linear nonthreshold (LNT) single-hit theory, the recommendation of the model by the US National Academy of Sciences, Biological Effects of Atomic Radiation I, Genetics Panel in 1956, and subsequent widespread adoption by regulatory ag...

Journal: :Dose-response : a publication of International Hormesis Society 2007
J Strzelczyk W Potter Z Zdrojewicz

Large segments of Western populations hold sciences in low esteem. This trend became particularly pervasive in the field of radiation sciences in recent decades. The resulting lack of knowledge, easily filled with fear that feeds on itself, makes people susceptible to prevailing dogmas. Decades-long moratorium on nuclear power in the US, resentment of "anything nuclear", and delay/refusal to ob...

Journal: :Dose-response : a publication of International Hormesis Society 2006
Peter A Parsons

Metabolic and energetic efficiency, and hence fitness of organisms to survive, should be maximal in their habitats. This tenet of evolutionary biology invalidates the linear-no threshold (LNT) model for the risk consequences of environmental agents. Hormesis in response to selection for maximum metabolic and energetic efficiency, or minimum metabolic imbalance, to adapt to a stressed world domi...

Health risks from asbestos exposures have been evaluated, considering past professional histories when exposures at workplaces were higher than today. A linear no-threshold (LNT) model has been applied, although its relevance is unproven. Fibers are often found in the lungs and pleura of deceased people. Fiber findings do not prove that a disease is caused by asbestos. It is reasonable to assum...

Journal: :Environmental Research 2021

This paper evaluates the scientific basis for adoption of linear non-threshold (LNT) dose response model radiation-induced leukemia. LNT risk assessment application leukemia is significant because it: (1) was generalized all tumor types induced by ionizing radiation and chemical carcinogens at relatively high doses and; (2) it based on mechanistic assumption low linearity somatic cell mutations...

Journal: :Dose-response : a publication of International Hormesis Society 2010
Yuchao Zhao Paolo F Ricci

For ionization radiation (IR) induced cancer, a linear non-threshold (LNT) model at very low doses is the default used by a number of national and international organizations and in regulatory law. This default denies any positive benefit from any level of exposure. However, experimental observations and theoretical biology have found that both linear and J-shaped IR dose-response curves can ex...

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