Switching between different alternative polyadenylation (APA) sites plays an important role in the fine tuning of gene expression. New technologies for the execution of 3'-end enriched RNA-seq allow genome-wide detection of the genes that exhibit significant APA site switching between different samples. Here, we show that the independence test gives better results than the linear trend test in ...

[1] Since the implementation of the international controls on ozone-depleting chemicals, an important focus in studies of stratospheric ozone has been on the detection of a turnaround in the downward trend. The usual statistical assumption of a piecewise linear representation of the trend does not account for the chemistry involved. Because the actual change is not expected to be piecewise line...

BACKGROUND The purpose of this study was to evaluate the effects of benzalkonium (BAK)-free travoprost monotherapy administered for 3 years on intraocular pressure and visual field performance. METHODS The intraocular pressure of 76 patients with normal tension glaucoma was monitored every 1-3 months. A Humphrey visual field test was performed every 6 months after treatment and compared with ...

Abstract—In industries, how to improve forecasting accuracy such as sales, shipping is an important issue. Correct sales forecasting is inevitable in industries. There are many researches made on this. In this paper, a hybrid method is introduced and plural methods are compared. Focusing that the equation of exponential smoothing method(ESM) is equivalent to (1,1) order ARMA model equation, a n...

Chloroplasts regulate their growth to optimize photosynthesis. Quantitative data show that the ratio of total chloroplast area to mesophyll cell area is constant across different cells within a single species and also across species. Wild-type chloroplasts exhibit little scatter around this trend; highly irregularly shaped mutant chloroplasts exhibit more scatter. Here we propose a model motiva...

climate change is defined as long term and irreversible changes in the climatic behaviorof a region. many studies have been conducted in different regions of the world on climatechange. the results of these studies show considerable changes in climatic factors especiallyin precipitation and temperature. in this research, the trend of changes in annual and seasonalrainfall and temperature in 24 ...

In this paper, we propose a modification of the multiple sinusoidal model such that periodic data observed with the presence of a trend component can be analyzed. In particular, we work with a linear trend model. But it can be developed similarly for the polynomial trend and the frequency model also. We consider the problem of estimation of frequency and amplitude parameters observed with a lin...

This paper extends the partially linear varying coefficient model to contain time trend and nonstationary variables as regressors. We use the profile likelihood method to estimate both time trend coefficient in the linear component and the functional coefficients in the nonlinear component and establish their asymptotic distributions. Monte Carlo simulations are shown to investigate the finite ...

The widely-used hydrological procedures for calculating events with T-year return periods from data that follow a Gumbel distribution assume that the data sequence from which the Gumbel distribution is fitted remains stationary in time. If non-stationarity is suspected, whether as a consequence of changes in land-use practices or climate, it is common practice to test the significance of trend ...