Successful new product development (NPD) activities need high amounts of new knowledge from a variety of different sources. When the NPD activities are seen as a process of knowledge accumulation, two knowledge processes are identified: knowledge acquisition and knowledge utilization. This study focuses on the process of knowledge acquisition from external knowledge sources in the NPD of SMEs. ...

Deposition and mobilization of fat in an organism are tightly controlled by multiple levels of endocrine and neuroendocrine regulation. Because these hormonal mechanisms ultimately act by affecting biochemical reactions of fat synthesis or utilization, obesity could be also modulated by altering directly the underlying lipid biochemistry. We have previously shown that genetically modified mice ...

The metabolic syndrome is a constellation of cardiovascular and metabolic risk factors associated with insulin resistance, which predisposes individuals to diabetes, and appears to be a multifactorial risk factor for cardiovascular disease, although its clinical significance remains controversial (1). Since it may become useful to be able to predict who will develop metabolic syndrome, we explo...

OBJECTIVE The metabolic syndrome (MS) is a cluster of cardiometabolic factors, which predisposes to diabetes and cardiovascular disease (CVD). Early detection of high-risk individuals for MS using accurate measures of insulin resistance (IR) could improve detection and prevention of CVD and diabetes. The aim of this study was to explore the ability of lipid accumulation product (LAP), compared ...

INTRODUCTION Lipid Accumulation Product (LAP) Index correlates to cardiovascular risk factors in general population but it has not been tested in hospitalized patients. OBJECTIVES We aimed to evaluate associations between LAP Index and metabolic profile in a tertiary hospital. METHODS Cross-sectional study with 90 inpatients. Lipid profile, fasting glucose, systolic and diastolic blood pres...

In individuals with sickle cell disease, a variable number of irreversibly sickled cells (ISC) is present that may contribute to the pathophysiology of sickle cell anemia. The present study was undertaken to determine the possible role of membrane lipid peroxidation in the genesis of ISC. After 24 hr of simple aerobic incubation, sickle cells accumulated 2-3 times more malonyldialdehyde (MDA), ...

Recent studies provide evidence that peroxisomal β-oxidation negatively regulates mitochondrial fatty acid oxidation, and induction of causes hepatic lipid accumulation. However, whether there exists a triggering mechanism inducing is not clear. Long-chain dicarboxylic acids are the product mono subjected to ω-oxidation, both ω-oxidation induced under ketogenic conditions, indicating might be c...

Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been shown to metabolize toxic aldehydes generated by lipid peroxidation, suggesting that it may serve as an antioxidant defense. To investigate its role in the late phase of ischemic preconditioning (PC), conscious rabbits underwent 6 cycles of 4-minute coronary occlusion/4-minute reperfusion. Twenty-four hours later, ...

CONTEXT AND OBJECTIVES The obesity paradox has already been established in relation to heart failure, but it is not known which obesity indicator best reflects this phenomenon. The aim of this study was to evaluate the association between obesity indexes and mortality among patients with heart failure. DESIGN AND SETTING Cohort study conducted in the Department of Cardiology of Hospital Nossa...