BACKGROUND Dyslipidemia has been noted to play an integral role in the pathogenesis and progression of micro and macrovascular complications in diabetes mellitus patients. The complications exemplified by renal vascular and cardiovascular disease cause the most morbidity and mortality in this group of patients. OBJECTIVE This study is aimed at understanding the pattern of dyslipidemia among t...

OBJECTIVE: This research was conducted to evaluate the prevalence of diabetic retinopathy (DR) in patients who were unaware of their eye condition. MATERIALS AND METHODS: A descriptive cross-sectional study was performed in a 12-month period on patients who were referred to Meybod Imam Sadegh Diabetes Center. 152 patients who had no eye complaint were selected. Pupil dilation was created by C...

The aim of this retrospective study was to evaluate the results of the immunosuppressive regiment in managing of IgA nephropathy associated with primary nephrotic syndrome at the Nephrology Clinic, University of Sarajevo Clinics Centre in period of 1997-2007. We studied 19 patients (4 women and 15 men) with idiopathic nephrotic syndrome, where pathomorphologic changes of IgA nephropathy were pr...

High levels of triglyceride-rich lipoproteins (TGRLs) in blood are linked to development of atherosclerosis, yet the mechanisms by which these particles initiate inflammation of endothelium are unknown. TGRL isolated from human plasma during the postprandial state was examined for its capacity to bind to cultured human aortic endothelial cells (HAECs) and alter the acute inflammatory response t...

Emerging data suggest that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) offer important benefits for the large population of individuals at high risk for coronary heart disease. This population encompasses a sizable portion of individuals who are also at high risk for drug-drug interactions due to their need for multiple medications. In general, statins are...

Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is endowed with a wide range of pharmacological properties whose therapeutic potential has only partly been exploited until now. Throughout complex and multifactorial mechanisms, OA exerts beneficial effects against diabetes and metabolic syndrome. It improves insulin response, preserves functionality and survival ...

BACKGROUND Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. DESIGN AND METHODS This is a retrospective multicenter European Group of Blood and Marrow Transplantation (EBMT) an...

Vol. 35 No. 4 • April 2010 • P&T® 197 INTRODUCTION Hyperlipidemia is extremely prevalent in both men and women today. Total cholesterol (TC) levels, as well as lowdensity lipoprotein-cholesterol (LDL-C) levels, usually increase throughout our lives. Nearly half of all Americans older than 20 years of age have TC levels exceeding 200 mg/dL. Only 50% of adults who qualify for lipid-lowering thera...