نتایج جستجو برای: lipogranulomatosis
تعداد نتایج: 79 فیلتر نتایج به سال:
Smoking Bans Yield Long-Term Benefits When it comes to linking cigarette smoke to heart attacks, one might assume that such a link would apply only as long as one is smoking or being exposed to secondhand smoke. That’s not necessarily true, however, at least according to a follow-up study of people living in and around Pueblo, Colorado. In the 2 January 2009 issue of Morbidity and Mortality Wee...
Smoking Bans Yield Long-Term Benefits When it comes to linking cigarette smoke to heart attacks, one might assume that such a link would apply only as long as one is smoking or being exposed to secondhand smoke. That’s not necessarily true, however, at least according to a follow-up study of people living in and around Pueblo, Colorado. In the 2 January 2009 issue of Morbidity and Mortality Wee...
466 | CANCER DISCOVERY MAY 2016 www.aacrjournals.org An international team of researchers— led by Susan Halabi, PhD, a professor of biostatistics at Duke University School of Medicine in Durham, NC—gathered information from nine phase III studies, encompassing 8,736 men with mCRPC. The patients in these trials had all received docetaxel as standard therapy. The researchers classifi ed them into...
Background: Aberrant b-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate b-catenin activity for therapeutic purposes have proven elusive to date. Methodology: To uncover genetic dependencies in breast cancer cells that harbor active b-catenin signaling, we performed RNAi-based loss-of-function screens in breast can...
BACKGROUND Farber Disease is an autosomal-recessively inherited, lysosomal storage disorder caused by acid ceramidase deficiency and associated with distinct clinical phenotypes. Children with significant neurological involvement usually die early in infancy, whereas patients without or only mild neurological findings suffer from progressive joint deformation and contractures, subcutaneous nodu...
Resnick LM, Gupta RK, Gruenspan H, Alderman M, Laragh J (1990). Hypertension and peripheral insulin resistance: mediating role of intracellular free magnesium. Hypertension. 3: 373-379. Rodríguez-Morán M, Guerrero-Romero F (2003) Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects. Diabetes Care. 26:1147–1152 Rosenbloom AL (1977) Serum c...
Purpose: Increasing evidence indicates that enhanced intratumoral androgen synthesis contributes to prostate cancer progression after androgen deprivation therapy. This phase II study was designed to assess responses to blocking multiple steps in androgen synthesis with inhibitors of CYP17A1 (ketoconazole) and type I and II 5α-reductases (dutasteride) in patients with castration-resistant prost...
Non–small cell lung cancer (NSCLC) has a poor prognosis, with substantial mortality rates even among patients diagnosed with early-stage disease. There are few effective measures to block the development or progression of NSCLC. Antiangiogenic drugs represent a new class of agents targeting multiple aspects of tumor progression, including cell proliferation, invasion, migration, and outgrowth o...
The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non–small cell lung carcinoma, LKB1 is somatically inactivated in 25% to 30% of cases, often concurrently with activating KRAS mutations. Here, we used an integrative approach to defi ne novel therapeutic targets in KRAS-driven LKB1 -mutant lung cancers. High-...
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