Introduction: The mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. The effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. To further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14C] clozapine with suita...

Sample load capacity, sample compatibility, influence of sample load on (3)H/(14)C counting efficiency, background count rate, figure of merit, quench resistance, and sample stability for nine selected, commercially available, liquid scintillation cocktails are presented in this study. The cocktails tested are Ecoscint A, Insta-Gel Plus, OptiPhase Hisafe 3, OptiPhase Trisafe, Ready Gel, SafeSci...

A 68 Ge source can be used to calibrate the positron detection eeciency of a liquid scintillation neutrino detector. A method to dissolve radioactive 68 Ge in pseudocumene-based liquid scintillator is described. The homogeneity of the source distribution has been studied and results for two Ge compounds are discussed. Light yield and light attenuation length of the liquid scintillator are not a...