The effects of an antacid containing magnesium and aluminum hydroxide on the pharmacokinetics of pefloxacin in 10 healthy volunteers were investigated. In a randomized crossover design, each subject received an oral dose of 400 mg of pefloxacin either with or without multiple doses of the antacid. The concentrations of pefloxacin and its metabolites in plasma and urine were determined by high-p...

Lithium nitride hydride, Li₄NH, was synthesised from lithium nitride and lithium hydride over minute timescales, using microwave synthesis methods in the solid state for the first time. The structure of the microwave-synthesised powders was confirmed by powder X-ray diffraction [tetragonal space group I4₁/a; a = 4.8864(1) Å, c = 9.9183(2) Å] and the nitride hydride reacts with moist air under a...

BACKGROUND The 23-amino acid extracellular domain of matrix 2 protein (M2e) and the internal nucleoprotein (NP) of influenza are highly conserved among viruses and thus are promising candidate antigens for the development of a universal influenza vaccine. Various M2e- or NP-based DNA or viral vector vaccines have been shown to have high immunogenicity; however, high cost, complicated immunizati...

This study examined the effects of widely used antacids (aluminum hydroxide, magnesium oxide, and calcium carbonate), ferrous sulfate, and ranitidine on the absorption of a fluorinated quinolone, (-)-(S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro- 7H- pyrido-[1,2,3,-de][1,4]benzoxazine-6-carboxylic acid hemihydrate (DR-3355), in healthy male volunteers enrolled in three sep...

Lithium-lanthanum zirconate (LLZ) can potentially be used as a solid electrolyte in lithium-metal batteries. Li-metal batteries offer superior charge capacities and higher energy densities compared to currently used Li-ion batteries. Lithium is highly reactive, which can be dangerous in consumer electronics, but a layer of LLZ electrolyte inserted alongside the Li-metal electrode greatly stabil...

A method for controlling the gastric pH of rabbits to low acidity (pH > 4) by using different antacids was investigated, and the physiological state of rabbits during gastric-acidity control and repeated bioavailability tests was also examined in terms of hemocytological and clinicobiochemical parameters. Neither dried aluminum hydroxide gel (DAH) nor synthetic aluminum silicate (SAS) could ele...

A system for the regeneratlon of caustic soda solutlons used In etching aluminum Invokes the hydrolysis of sodium aluminate to llberate free sodium hydroxide and produce a dry, crystalllne hydrated alumlna byproduct. The system has been used extenslvely In Japan, and, by adjusting process parameters, can be adapted to North American practice. By otlllting the system in a typical plant, soild ai...

Studies were conducted to compare the phosphate-binding efficacy of lanthanum carbonate directly with other clinically used phosphate binders and to evaluate any potential adverse pharmacology. To examine the phosphate-binding efficacy, rats with normal renal function and chronic renal failure received lanthanum carbonate, aluminum hydroxide, calcium carbonate, or sevelamer hydrochloride in sev...