Alcohol use disorders and alcohol dependency affect millions of individuals worldwide. The impact of these facts lies in the elevated social and economic costs. Alcoholic liver disease is caused by acute and chronic exposure to ethanol which promotes oxidative stress and inflammatory response. Chronic consumption of ethanol implies liver steatosis, which is the first morphological change in the...

Liver disorders constitute a worldwide increasing problem. Both the study of mechanisms underlying liver disease and development therapeutics heavily rely on use experimental models. Among those, human-based in vitro systems are more preferred over laboratory animals because ethical reasons. Primary human hepatocytes their cultures still considered as gold standard liver-based models, they prov...

Background and aimLiver transplants cases have been rising becoming the choice of treatment for many patients with end stage liver diseases. With an increasing number qualified centers facilities, effectiveness observed to increase over years. But success quality life post transplant has be influenced due psychiatric comorbidities.MethodWe searched literature using terms ‘Psychosocial factors’,...

Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver complications, depression, dyspepsia, spleenic congestions, varicose veins, diabetes, amenorrhea, uterine h...

PURPOSE The goal of this study was the early diagnosis of ABCB11 spectrum liver disorders, especially those focused on benign recurrent intrahepatic cholestasis and progressive familial intrahepatic cholestasis. METHODS Fifty patients presenting neonatal cholestasis were evaluated to identify underlying etiologies. Genetic analysis was performed on patients suspected to have syndromic disease...

aim : the aim of present study was to screen two categories of psychiatric disorders in chronic functional constipation. background : it has been established that the prevalence of mood and anxiety disorders among patients with functional gastrointestinal disorders is higher than in the general population. patients and methods : fifty four constipated patients were recruited from patients refer...

Pregnant women may be affected by diseases of the gastrointestinal tract or liver. These disorders can be related or unrelated to pregnancy. Conditions unrelated to pregnancy can be pre-existing or co-incident. These diseases have varying effects on obstetric outcome. Severe liver disease in pregnancy is rare. We present some common gastrointestinal and liver disorders focussing on the diagnosi...

conclusions hepatocyte isolation can be performed as the main and initial step for cell transplantation from unused/rejected liver. it is the first experience in iran. results highly quality hepatocytes with high viability and low contamination were isolated. the mean viability was 71.8% ± 21.7. in the first 4 cases microbial contamination by staphylococci, diphtheroid and klebsiella was detect...