BACKGROUND AND AIMS The liver is the main source and insulin the main regulator of IGF binding protein 1 (IGFBP-1) in humans. Here we examined how serum IGFBP-1 concentrations are related to directly measured hepatic insulin sensitivity and liver fat content in humans. METHODS We measured fasting serum (fS) IGFBP-1 concentrations and liver fat content by proton magnetic resonance spectroscopy...

Introduction: Obesity is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD). While Magnetic Resonance Imaging (MRI) is a non-invasive gold standard to detect fatty liver, we demonstrate a low-cost and portable electrical impedance tomography (EIT) approach with circumferential abdominal electrodes for liver conductivity measurements. Methods and Results: A finite elem...

Objective: Tea, camellia sinensis, which is used as a popular beverage in Iran, may reduce the risk of cardiovascular diseases suchas coronary heart disease (CHD). In this investigation, we studied the effect of Iranian black and green tea on serum and liver lipid profile which is closely associated with obesity and many cardiovascular diseases. Materials and Methods: 24 male adult Wistar rats...

Context Polycystic ovarian syndrome (PCOS) is often associated with obesity and diabetes. Objective The present study measured body fat distribution and metabolic risk factors in women with features of PCOS. Design Cross-sectional, multiethnic study of cardiovascular risks. Setting General community. Study Participants 145 PCOS and 344 non-PCOS women. Exposure Measures Body compositio...

AIM To estimate the impact of high fat diet and estrogen deficiency on the oxidative and antioxidative status in the liver of the ovariectomized rats, as well as the ameliorating effect of physical activity or consumption of functional food containing bioactive compounds with antioxidative properties on oxidative damage in the rat liver. METHODS The study was conducted from November 2012 to A...

Non-alcoholic fatty liver disease and the risk of progression to steatohepatitis, cirrhosis and hepatocellular carcinoma have been identified as major public health concerns. We have demonstrated the feasibility and potential value of measuring liver fat content by magnetic resonance imaging (MRI) in a large population in this study of 4,949 participants (aged 45-73 years) in the UK Biobank ima...

Due to the shortage of healthy donor organs, steatotic livers are commonly used for transplantation, placing patients at higher risk for graft dysfunction and lower survival rates. Raman Spectroscopy is a technique which has shown the ability to rapidly detect the vibration state of C-H bonds in triglycerides. The aim of this study is to determine whether conventional Raman spectroscopy can rel...

objective: persian leek is one of the most widely used herbal foods among iranians. in this study, effects of oral administration of persian leek on plasma and liver lipids were examined in hamster. materials and methods: male syrian hamsters were randomly divided into three groups: control (standard diet), high fat control (high-fat/high-cholesterol diet), persian leek (high-fat/high-cholester...

OBJECTIVE The purpose of this study was to determine whether type 2 diabetic patients have more liver fat than age-, sex-, and BMI-matched nondiabetic subjects and whether liver enzymes (serum alanine aminotransferase [S-ALT] and serum aspartate aminotransferase) are similarly related to liver fat in type 2 diabetic patients and normal subjects. RESEARCH DESIGN AND METHODS Seventy type 2 diab...

BACKGROUND The central feature of NAFLD is a disturbed fatty-acid metabolism with hepatic lipid accumulation. However, the factors that determine the severity of NAFLD, including the role of nutrition, gender, and plasma lipid levels, remain to be determined. METHODS High-fat diets (42 en% fat), containing 0.2% cholesterol, were fed to male and female wild-type and hyperlipidemic APOE2ki C57B...