Under subcell discretisation for viscoelastic flow, we have given further consideration to the compatibility of function spaces for stress/velocity-gradient approximation (see [JNNFM, special issue AERC 2006). This has been conducted through the three scheme discretisations (quad-fe(par), fe(sc) and fe/fv(sc)). In this companion study, we have extended the application of the original implementa...

The macrocycle family of molecules called cucurbit[n]urils are potential drug delivery vehicles as they are able to form host-guest complexes with many different classes of drugs. This study aimed to examine the utility of Cucurbit[6]uril (CB[6]) in topical cream-based formulations for either localised treatment or for transdermal delivery. Cucurbit[6]uril was formulated into both buffered crea...

Tight junctions (TJs) link adjacent cells and are critical for maintenance of apical-basolateral polarity in epithelial monolayers. The TJ protein occludin functions in disparate processes, including wound healing and Hepatitis C Virus infection. Little is known about steady-state occludin trafficking into and out of the plasma membrane. Therefore, we determined the mechanisms responsible for o...

In recommendation systems, one is interested in the ranking of the predicted items as opposed to other losses such as the mean squared error. Although a variety of ways to evaluate rankings exist in the literature, here we focus on the Area Under the ROC Curve (AUC) as it widely used and has a strong theoretical underpinning. In practical recommendation, only items at the top of the ranked list...

We consider a Mode III lattice with an interface layer where the dynamic crack growth is caused by a localised sinusoidal wave. In the wave–fracture scenario, the ‘feeding wave’ (here also called the knife wave) delivers energy to the moving crack front, while the dissipative waves carry a part of this energy away from the front. The questions addressed here are: What are the conditions of exis...