نتایج جستجو برای: localized scleroderma
تعداد نتایج: 109929 فیلتر نتایج به سال:
INTRODUCTION Scleroderma is an autoimmune disease that involves the connective tissue characterized by skin fibrosis, classified as localized and systemic (participation of one or more internal organs). The primary objective of this study is to describe and analyze the clinical and laboratory findings in a group of children diagnosed with scleroderma at a referral hospital. MATERIAL AND METHO...
Hospital Physician January 2008 33 S ystemic sclerosis, or scleroderma, is a rare connective tissue disease of unknown etiology. The word scleroderma, derived from the Greek words scleros for hard and derma for skin, refers to the hallmark finding of chronic hardening and thickening of the skin that occurs in this disease. The clinical manifestations of systemic sclerosis range from localized s...
OBJECTIVE Classification criteria for systemic sclerosis (SSc; scleroderma) are being updated. Our objective was to select a set of items potentially useful for the classification of SSc using consensus procedures, including the Delphi and nominal group techniques (NGT). METHODS Items were identified through 2 independent consensus exercises performed by the Scleroderma Clinical Trials Consor...
BACKGROUND Morphea is an inflammatory autoimmune skin sclerosis of unknown etiology. A causative role of Borrelia burgdorferi infection has been controversially discussed, but no conclusive solution has yet been achieved. OBJECTIVE Intrigued by 3 young patients with severe Borrelia-associated morphea and high-titer antinuclear antibodies, we retrospectively examined the relationship between B...
Morphea is a localized form of scleroderma characterized by sclerotic plaques limited to the skin. Although its cause is unknown, genetic, infectious and autoimmune mechanisms have been suggessed in the pathogenesis of the morphea. It is more common among childen and young women. Although the prognosis is generally good, it sometimes causes significant morbidity. Morphea has five subtypes as pl...
Fibrosis is a pathologic process in which deposition of abnormal extracellular matrix by fibroblasts leads to the loss of normal tissue structure and function. In skin, fibrosis is associated with several diseases, including systemic sclerosis, localized scleroderma, nephrogenic systemic fibrosis, and keloid scars. Currently, effective targeted therapies to reverse or prevent fibrosis are lacking.
Progressive facial hemiatrophy or Parry-Romberg Syndrome is a rare disease characterized by atrophy in subcutaneous tissues on skin on one half of the face and some accompanied systematic findings. Generally, it develops before the age of 20. It is quite difficult to discriminate it from linear scleroderma localized in fronto-parietal area as they have similar clinical characteristics. In this ...
L. Vaillant, Service de dermatologie, CHU Trousseau, F-37044 Tours Cedex (France) We read with great interest a recent article by Aberer et al. [1] published in your journal. They investigated different types of mor-phea, and 46% of their patients were sero-positive for Borrelia burgdorferi. These authors have hypothesized yet in 1985 that localized scleroderma might be a late manifestation of ...
SHARE – workpackage 5: evidence based recommendations for diagnosis and treatment of juvenile localized scleroderma and juvenile systemic sclerosis Roberta Culpo, Sebastian J Vastert, Angelo Ravelli, Nico Wulffraat, Ivan Foeldvari, Francesco Zulian, Jordi Anton, Tadej Avcin, Eileen Baildam, Christina Boros, Jeffrey Chaitow, Tamas Constantin, Pavla Dolezalova, Ozgur Kasapcopur, Sheila Knupp de O...
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