Introduction Aseptic loosening is the most common cause of total hip arthroplasty (THA) failure and revision surgery. Genetic polymorphisms could be determinant factors for implant loosening. Source of data We performed a comprehensive search of Medline, CINAHL, Googlescholar, Embase and Cochrane databases, using various combinations of the keyword terms 'aseptic loosening', 'gene', 'hip artho...

Sir,?With reference to Senior Sub-Asst. Surgeon C. R. Chetty's reply in your August number, to my query I may state that I was not ignorant of the definition of Grievous Hurt. Now the question for decision is whether loosening of a tooth conns under the bending of dislocation ? Dislocation means forcible displacement, of one of the bones entering into an articulation, as the result of an injury...

In his 1881 book, The Power of Movement in Plants, Darwin described a now classic experiment in which he directed a tiny shaft of sunlight onto the tip of a grass seedling. The region below the coleoptile tip subsequently curved toward the light, leading to the notion of a transmissible growth stimulus emanating from the tip. Two generations later, follow-up work by the Dutch plant physiologist...

Sir,—The hypothesis of wear particles causing foreign-body reaction, periprosthetic osteolysis and eventually prosthetic loosening was already put forward in the 1970s (Brinkmann and Heilmann 1974, Willert et al. 1974). The term cement disease was coined in the 1980s (Jones and Hungerford 1987), generalized to particle disease in the 1990s (Harris 1994), and wear particles are still widely cons...

Aseptic loosening remains the commonest cause of failure of total hip arthroplasty. Cement mantle defects are associated with aseptic loosening. Cementing technique has a profound influence on the incidence of aseptic loosening of total hip replacements. Two specific measures that seem to have the greatest impact on the longevity of cemented femoral stems are pressurization of cement and contro...

We reviewed 351 cemented revisions of femoral stems performed for aseptic loosening. At a mean of six years after the revision operation 72.1% of the patients were pain-free and 21.4% had only mild or occasional discomfort. The latest radiographs showed definite stem loosening in 10 (2.8%) and 20 hips (5.7%) had required rerevision, only nine (2.6%) of which were for mechanical failure of the s...