UNLABELLED Urinary retention is uncommon in children and only one case has been described in literature with loperamide treatment. We report the occurrence of prolonged urinary retention in a 10-years-old girl after receiving oral loperamide for an acute gastroenteritis. The first episode of urinary retention lasted for 24 hours; radiological evaluation (Magnetic Resonance, cistography and rena...

Purpose of current research work was to develop mouth dissolving tablets of Loperamide HCl with enhanced solubility and palatable taste. Mouth dissolving tablets of Loperamide HCl were prepared by the directcompression method. Skimmed milk was used as natural polymer. Improvement in dissolution rate of drug was observed in solid dispersion as compared to pure drug. All the batches of the tablet...

The effect of acute oral administration of three different doses (4, 8, and 16 mg) of loperamide, a peripheral opiate agonist, on basal and submaximal pentagastrin-stimulated gastric acid secretion was evaluated in healthy volunteers. Both basal and stimulated gastric secretion were significantly lowered by 8 and 16 mg of the drug in comparison with a control study, while 4 mg was ineffective. ...

the other two agents in improving stool consistency and relieving urgency (Palmer et al., 1980). Side effects. Diphenoxylate causes more side effects than either codeine phosphate or loperamide. Both codeine and diphenoxylate cross the blood-brain barrier and may cause central-nervous-system side effects such as nausea, dizziness, drowsiness and depression. Loperamide does not usually cross the...

BACKGROUND The peripheral immune-derived opioid analgesic pathway has been well established as a novel target in the clinical pain management of a number of painful pathologies, including acute inflammatory pain, neuropathic pain, and rheumatoid arthritis. OBJECTIVE Our objective was to engineer targeted nanoparticles that mimic immune cells in peripheral pain control to deliver opioids, in p...

OBJECTIVE To investigate the change of loperamide-induced prostate relaxation in rats fed with high-fat diet (HFD). MATERIALS AND METHODS Adult male Wistar rats were divided into 2 groups: (1) control rats fed with normal chow and (2) rats fed with HFD for 6 months. The prostate was removed for histology study. Isolated prostate strips were hung in organ bath and precontracted with 1 μmol/L p...

BACKGROUND Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the present study was to evaluate the effects of Salecan on fecal output and small intestinal transit in normal and two models of drug-induced constipation mice. METHODS ICR mice were a...

BACKGROUND Chemotherapy-induced diarrhea (CID) is a common side effect of a number of chemotherapeutic agents. Conventional therapy for severe CID with opioids or loperamide is moderately effective. A prospective trial was conducted using octreotide acetate for treatment of severe CID refractory to loperamide. PATIENTS AND METHODS Thirty-two patients with grade 2 and 3 CID refractory to loper...

The efflux transporter P-glycoprotein, expressed at high levels at the blood-brain barrier, exerts a profound effect on the disposition of various therapeutic compounds in the brain. A rapid and efficient modulation of this efflux transporter could enhance the distribution of its substrates and thereby improve central nervous system pharmacotherapies. This study explored the impact of the intra...