PURPOSE Intravenous lorazepam is considered the drug of first choice for control of acute convulsive seizures. However, resource or personnel constraints necessitate the study of alternative routes and medications. This study compared the efficacy and adverse effects of intranasal versus intravenous lorazepam in children aged 6-14 years who presented with acute seizures. METHODS This was a ra...

Sir, We read with interest the study by Payee et al. (1999). Authors remark that no study on the treatment of catatonia with lorazepam has been carried out in India. In this context, we would like to mention that a similar but more exhaustive study has been conducted by us on a larger patient population at Central Institute of Psychiatry, Ranchi. We share a few findings from our study, which is...

In an open-label, prospective non-randomized cohort study, we compared the effectiveness and tolerability profiles of the homeopathic remedy Nervoheel N with those of the benzodiazepine, lorazepam, in 248 patients with insomnia, distress, anxieties, restlessness or burnout and similar nervous conditions ('mild nervous disorders'). Patients were treated with Nervoheel N or lorazepam at the recom...

AIMS The study aimed at comparing the fixed tapering dose and the symptom-triggered regimens of lorazepam for alcohol detoxification. METHODS We carried out a prospective, randomized, double blind controlled trial involving 63 consecutive consenting male patients admitted with diagnosis of uncomplicated alcohol withdrawal. The patients were randomized into two groups based on the type of lora...

Entomotoxicology is based on using insect evidence recovered from a dead body to find out the cause and time of death. Drugs can accumulate in fly larvae when they ingest flesh deceased persons alter normal development causing implications calculating postmortem intervals. Lorazepam an antidepressant generally used treat anxiety. Larvae Chrysomya rufifacies were fed beef liver mixed with loraze...

OBJECTIVE This prospective observational study compared the effectiveness and acceptability of three commonly used regimens to reduce pain during first-trimester surgical abortion with local anesthesia. METHOD Women undergoing suction curettage at less than 14 weeks gestation received preoperative ibuprofen and an intraoperative paracervical block. Participants then selected (1) no additional...

STUDY OBJECTIVES To determine if systemic administration of selected sedative-hypnotics that modulate the function of the y-amino-butyric acid-A (GABAA) receptor can: (i) delay arousal thereby allowing genioglossus (GG) activity to increase more in response to respiratory stimulation during sleep, (ii) also cause the robust increase in GG activity during undisturbed sleep recently observed with...