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The objective of the present study was to assess the effect of cyclosporine (CsA) on the pharmacokinetic parameters of mycophenolic acid (MPA), an active mycophenolate mofetil (MMF) metabolite, and to compare with the effect of everolimus (EVR).Anonymized medical records of 404 kidney recipients were reviewed. The main MPA pharmacokinetic parameters (AUC(0-12) and Cmax) were evaluated.The patie...

BACKGROUND Pancreas-specific complications (PSCs), comprising postoperative pancreatic fistula, haemorrhage and intra-abdominal collections, are drivers of morbidity and mortality after pancreaticoduodenectomy (PD). A serum amylase concentration of 130 units/l or more on postoperative day (POD) 0 has been shown to be an objective surrogate of pancreatic texture, a determinant of PSCs. This stud...

The role of dietary cholesterol in people with diabetes has been little studied. We investigated the effect of a hypoenergetic high-protein high-cholesterol (HPHchol) diet compared to a similar amount of animal protein (high-protein low-cholesterol, HPLchol) on plasma lipids, glycaemic control and cardiovascular risk markers in individuals with type 2 diabetes. A total of sixty-five participant...

F is an important trace element for bones and teeth. The protective effect of F against dental caries is well established. Urine is the prime vehicle for the excretion of F from the body; however, the relationship between F intake and excretion is complex: the derived fractional urinary F excretion (FUFE) aids understanding of this in different age groups. The present study aimed to investigate...

The heat capacities of tripeptides N-formyl-l-methionyl-l-leucyl-l-phenylalaninol (N-f-MLF-OH) and N-formyl-l-methionyl-l-leucyl-l-phenylalanine methyl ester (N-f-MLF-OMe) were measured by precision adiabatic vacuum calorimetry over the temperature range from T = (6 to 350) K. The tripeptides were stable over this temperature range, and no phase change, transformation, association, or thermal d...

let $r$ be a commutative ring with identity‎. ‎a proper ideal $p$ of $r$ is a $(n-1,n)$-$phi_m$-prime ($(n-1,n)$-weakly prime) ideal if $a_1,ldots,a_nin r$‎, ‎$a_1cdots a_nin pbackslash p^m$ ($a_1cdots a_nin pbackslash {0}$) implies $a_1cdots a_{i-1}a_{i+1}cdots a_nin p$‎, ‎for some $iin{1,ldots,n}$; ($m,ngeq 2$)‎. ‎in this paper several results concerning $(n-1,n)$-$phi_m$-prime and $(n-1,n)$-...

Diet is important for the prevention of CVD, and diets high in MUFA might be more cardioprotective than low-fat diets. We hypothesise that inflammation and endothelial cell function will be improved most favourably by a high-MUFA diet compared with a low-fat diet. This was tested in a parallel randomised intervention trial on overweight individuals (aged 28·2 (SD 4·6) years) assigned to a diet ...

Silicic acid uptake kinetics for a field population of benthic diatoms were examined using a radioisotope tracer over a concentration range of 0-300 μmol L. The microphytobenthos half saturation constant (54 μmol L) and specific uptake rates (0.096 h) for silicic acid were well above those usually found in the pelagic environment. Silicic acid kinetics were hyperbolic only at low concentrations...