Ataxia telangiectasia (AT) homozygotes have an increased risk for development of malignancies. Our patient, despite frequent courses of antibiotics, displayed persistent pulmonary infiltration, fever, and mediastinal enlarged lymph nodes on thoracic computed tomography. No infectious etiologies were established for the persistent pulmonary findings by fine needle biopsy, bronchopulmonary lavage...

The aim of the study was to investigate the contribution that open lung biopsy makes to the management of children with diffuse interstitial lung disease and to review the procedure-related morbidity in comparison with published literature on other biopsy techniques. The authors reviewed the case notes and histology of patients under 18 yrs who had had an open lung biopsy in 1991-1998 for inves...

BACKGROUND Subacute bacterial endocarditis (SBE) occasionally exhibits positive cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA) of the anti-proteinase-3 (PR-3) type. Clinically, it mimics ANCA-associated vasculitis, such as Wegener's disease with glomerulonephritis. Lung abscesses are the most common manifestation of lung involvement. We herein report a case of culture-negative SBE st...

The results of high speed air drill lung biopsy during 38 months in Addis Ababa is reported. Even though the diagnostic yield was only 49%, trephine lung biopsy has a place in the investigation of diffuse and accessible localised lesions of the lung. It has proved to be a relatively safe and simple procedure. Nineteen male and 20 female patients were studied and in addition eight postmortem spe...

The diagnosis and treatment of lung cancer have evolved into the era of precision medicine. Liquid biopsy, a minimally invasive approach, has emerged as a promising practice in genetic profiling and monitoring of lung cancer. Translating liquid biopsy from bench to bedside has encountered various challenges, including technique selection, protocol standardisation, data analysis and cost managem...

At cardiac catheterization, 93 pulmonary wedge angiograms were performed in 85 patients with congenital heart defects. The pulmonary wedge angiogram was quantitatively analyzed and the findings were compared with hemodynamic features and morphometric assessment of lung biopsy tissue when available (27 patients). A pulmonary wedge catheter was directed into the right or left lower lobe to the or...