Several lipocalins contain conserved amino acid sequences similar to the phosphodiester bond cleavage domain of sugar non-specific magnesium-dependent nucleases of the Serratia marcescens type. His-89 and Glu-127 of the S. marcescens endonuclease are believed to have a role in the active catalytic site by the attack of a water molecule at the phosphorus atom of the bridging phosphate. Tear lipo...

[1], belongs to the lipocalin family of proteins. These are typically small secreted proteins characterised by their ability to bind small, hydrophobic molecules in a structurally conserved pocket formed by a β-pleated sheet, and to form macromolecular complexes. Many lipocalins also bind to specific cell-surface receptors, but so far no NGAL receptor has been identified. NGAL has many synonyms...

Lipocalin-2 (LCN2) has been implicated in promoting apoptosis and neuroinflammation neurological disorders; however, its role neural transplantation remains unknown. In this study, we cultured differentiated Lund human mesencephalic (LUHMES) cells into dopaminergic-like neurons found that LCN2 mRNA was progressively induced mouse brain after the intrastriatal of neurons. The induction protein d...

Introduction: Obesity and hypertension are associated with organ complications, including kidney diseases. It is necessary to search for the methods of early detection these complications. Aim: The aim study was assess renal function in obese adolescents, based on lipocalin-2 cystatin C levels relation creatinine, estimated glomerular filtration rate leptin levels. Materials methods: included 7...