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تعداد نتایج: 91 فیلتر نتایج به سال:
The transcription factor (TF) SOX2 is essential for the maintenance of pluripotency and self-renewal in embryonic stem cells. In addition to its normal stem cell function, SOX2 over-expression is associated with cancer development. The ability to selectively target this and other oncogenic TFs in cells, however, remains a significant challenge due to the 'undruggable' characteristics of these m...
Polycomb group (PcG) genes encode evolutionarily conserved transcriptional repressors that are required for the long-term silencing of particular developmental control genes in animals and plants. PcG genes were first identified in Drosophila as regulators that keep HOX genes inactive in cells where these genes must remain silent during development. Here, we report the results of a genetic scre...
The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are diminished in ageing and neurodegenerative disorders, including Alzheimer's disease and Huntington's disease. The epigenetic mechanisms that (dys)regulate transcription of Dlg4/PSD95, or other plasticity genes, are largel...
The humanoid bipedal locomotion requires computationally efficient solutions of the navigation and inverse kinematics problems. This paper presents analytic methods, using tools from computational geometry and techniques from the theory of Lie groups, to develop new geometric algorithms for the navigation path planning, locomotion movement, and kinematics modeling of humanoid robots. To solve t...
This study aims to describe, analyze, and interpret the implementation of local regulation no. 7 2017 concerning public order, especially social order by Tomohon Civil Service Police Unit [1]. The results showed that: a) lack understanding community regarding what are benefits, goals objectives regulations does not know because socialization carried out implementor, so far has been only in oral...
Water stress has become one of the foremost constraints to agricultural development, mostly in areas that are deficient water. A field trial been conducted evaluate performance different twenty wheat genotypes under three treatments viz., control (T0) = normal watering, stress-1 (T1) water from tillering up maturity, and stress-2 (T2) anthesis maturity were used as treatments. The results revea...
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