there is interrelationship between the immune and nervous systems that is accomplished by the molecular mediators. dopamine is one of the most important neurotransmitters. five different dopamine receptor genes (drd1, drd2, drd3, drd4, and drd5) have been recognized and cloned. the expression of the dopamine receptors is well characterized in the brain but little work has been done to examine t...

In an attempt to improve our gene transfer efficiency into hematopoietic stem cells and to evaluate the capacity of immunoselected CD34+Thy-1+(CDw90) cells to reconstitute hematopoiesis following myeloablation, bone marrow (BM) transplantation was performed using autologous, immunoselected CD34+Thy-1+ cells in rhesus macaques. BM samples were positively selected for cells that express CD34, fur...

This study covered a population of 91 cows aged 3-6 years. Enzootic bovine leukaemia (EBL) was diagnosed with ELISA and PCR tests. The assays were performed in the 1, 2, and 3 month after calving. Use was made of anti-bovine monoclonal antibodies (Mab), (VMDR Inc. Pullman-USA) and conjugates of FITC and R-PE (Medac – Germany) with an indirect immunofluorescence reaction (IMF). A differentiation...

Tritiated thymidine-labeling data in individual and parabiotic rats showed that macrophages in peritoneal exudates were derived from cells in the blood which were the progeny of rapidly and continuously proliferating precursors. The characteristics of this population identify them with free macrophages studied in other sites; similarly, they can be obtained from transfused bone marrow. Cells in...

Rather unexpectedly, major histocompatibility complex class II-deficient mice have a significant population of peripheral CD4+ T lymphocytes. We have investigated these cells at the population and clonal levels. CD4+ T lymphocytes from class II-deficient animals are thymically derived, appear early in ontogeny, exhibit the phenotype of resting memory cells, are potentially functional by several...

Exposure of lymphocytes from F2 hybrid and backcross rats of the PVG and DA strains to inter-parental strain alloantisera and complement frequently and unexpectedly revealed incomplete susceptibility within a population of cells. This heterogeneity did not appear to result from variable susceptibility to cytotoxic mechanisms. A more likely explanation was that variation occurred in the expressi...

We have defined two subpopulations of B lymphocytes in chronic lymphocytic leukemia (CLL). The major variant (termed typical) was characterized by the presence of a relatively homogeneous population of small-to-medium-sized lymphocytes with low-density SmIgM and no evidence of intracellular Ig synthesis. A minor group (termed atypical) was identified by the presence of a pleomorphic cell popula...

In three patients with chronic myelocytic leukemia who were heterozygous at the X-linked glucose-6-phospháte dehydrogenase locus, lymphocytes were studied to determine if they had the same stem cell origin as the leukemic myeloid cells. Normal tissues such as skin had both B and A glucose-6-phosphate dehydrogenase isoenzymes, but the leukemic myelogenous cells displayed only one isoenzyme type,...

Patients with sarcomas circulate a population of lymphocytes that exert cytotoxicity to cultured sarcoma cells; these lymphocytes behave as if pre­ sensitization to sarcoma-distinctive antigen(s) occurred already in vivo. This cytotoxic effect can be abrogated by sarcoma-specific blocking serum factors. Another “noncommitted” population of lymphocytes may gain d e novo immune reactivity to allo...

1Supported by USPHS Grants GM 01496 and GM 10548. Received February 20, 1974; accepted June 12,1974. lymphomas, the tumor type that accumulates 67Ga avidly; (ft) T-lymphocytes have been shown to be present in large numbers at the sites of abscesses, which also accumulate 67Ga well; and (c) T-lymphocytes are able to be transformed readily with mitogens, thereby converting a quiescent, nondividin...