OBJECTIVE This study aimed to describe self-reported patterns of use and effects of lysergic acid diethylamide (LSD) analogues (AL-LAD, 1P-LSD, and ETH-LAD) and the characteristics of those who use them. METHODS An anonymous self-selected online survey of people who use drugs (Global Drug Survey 2016; N = 96,894), which measured perceived drug effects of LSD and its analogues. RESULTS Most ...

L1 not onlv during the operahon proper but also postopel'atwely To thas end, sever~ means, mechamcal as well as chemical, are made available by modem therapy, apart horn sound prophylaxis Such prophylactic treatment consists of the use Of an adequate but non-depressant premedmahon and laght ~anaesthesaa winch will allow both optimum oxygenation and venhlahon The vcntdatlon may then l:e measured...

100-word speech samples of alcoholic and schizophrenic Ss were examined in order to relate characteristics of these samples to the differential predictability of (a) alcoholic speech under drug versus nondrug conditions (LSD-25), and (b) schizophrenic and alcoholic speech, using the cloze procedure. The deleted words in the samples were identified as to grammatical class form and frequency of u...

One of the most significant trends in American culture today is what might be considered an anti-intellectual or anti-scientific trend, two of whose main highlights are the tremendously widespread use of psychedelic drugs, such as marijuana and LSD, and the tremendously increasing interest in various oriental and mystical religions. The states of consciousness produced by drugs or meditation ar...

Wacker et al. report the crystal structure of LSD in complex with one of its major targets in the brain, the 5-HT2B receptor, the first such structure for any psychedelic drug. The results shed light on the molecular mechanisms underlying its ability to induce hallucinations with greater duration and potency than closely related compounds.

This article aims to explore, through established scientific research and documented accounts of personal experience, the similarities between religious mystical experiences and some effects of D-lysergic diethylamide or LSD. LSD predominantly works upon the serotonergic (serotonin-using neurons) diffuse neuromodulatory system, which projects its axons to virtually all areas of the brain includ...

Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated with the potent hallucinogen known as lysergic acid diethylamide (LSD); however, since 2013 blotter stamps with N-2 methoxybenzyl-substituted phenylethylamine hallucinoge...

in this report that C. nocturnum is both LD and LSD in its responses and that the previously reported critical day length is for the LD responses while the LSD response has a critical day length of between 12 and 16 hours. This more clearly defining of the 2 responses in C. nocturnum brings into focus the previously suggested questions as to whether a single hormone can he synthesized as a resu...

A new antibody to lysergic acid diethylamide (LSD) was used to develop a novel indirect ELISA for the quantification of drug in urine. Evaluation of the new assay with the commercially available LSD ELISA (STC Diagnostics) shows improved performance. The test requires 50 microL of urine, which is used to measure concentrations of drug in the microg/L to ng/L range. The limit of detection was 8 ...

Salvinorin A, a neoclerodane diterpene, is the most potent naturally occurring hallucinogen known and rivals the synthetic hallucinogen lysergic acid diethylamide in potency. Recently, the molecular target of salvinorin A was identified as the kappa opioid receptor (KOR). Salvinorin A represents the only known non-nitrogenous KOR selective agonist. Based on the selectivity of salvinorin A for t...