From a combination of deep Hubble Space Telescope V and I images with groundbased images in the same bands, we have obtained color–magnitude diagrams of M10, M22, and M55, extending from just above the hydrogen burning limit to the tip of the red giant branch, down to the white dwarf cooling sequence. We have used the color-magnitude arrays to extract main sequence luminosity functions (LFs) fr...

The Nightfire algorithm detects and characterizes sub-pixel hot sources using multispectral data collected globally, each night, by the Suomi National Polar Partnership (NPP) Visible Infrared Imaging Radiometer Suite (VIIRS). The spectral bands utilized span visible, near-infrared (NIR), short-wave infrared (SWIR), and mid-wave infrared (MWIR). The primary detection band is in the SWIR, centere...

The spectrophotometric methods M6, M7, M8 and M10 for the determination of Zolmitriptan in pure and dosage forms have been described in this paper. The present methods involve the determination of Zolmitriptan in pharmaceutical dosage at the given optimum conditions. The stock solution (1.0 mg/mL) of Zolmitriptan was prepared by dissolving 100 mg of the drug in 10.0 mL of methanol and made up t...

The aim of this paper is to describe a systematic way of constructing effective divisors on Mg having exceptionally small slope. In particular, these divisors provide a string of counterexamples to the Harris-Morrison Slope Conjecture (cf. [HMo]). In a previous paper [FP], we showed that the divisor K10 on M10 consisting of sections of K3 surfaces contradicts the Slope Conjecture on M10. Since ...

The purpose of this study was to investigate the metabolism and disposition of fluticasone furoate, an enhanced-affinity glucocorticoid receptor agonist, in humans. In a two-part, open-label design study, five healthy male subjects received a p.o. dose of 2 mg of [(14)C]fluticasone furoate, followed 4 weeks later by an i.v. dose of 0.25 mg of [(14)C]fluticasone furoate (as a 30-min infusion). O...

To construct maternal phylogeny and prehistoric dispersals of modern human being in the Indian sub continent, a diverse subset of 641 complete mitochondrial DNA (mtDNA) genomes belonging to macrohaplogroup M was chosen from a total collection of 2,783 control-region sequences, sampled from 26 selected tribal populations of India. On the basis of complete mtDNA sequencing, we identified 12 new h...

With the aid of monoclonal antibodies directed against a specific site on the hemagglutinin-neuraminidase surface glycoprotein, four mutants of the Kilham neurotropic strain of mumps virus were isolated. All four mutants had increased neuraminidase activity. Two mutants (M10 and M12) lost their hemagglutination capacity with human O erythrocytes but retained their ability to agglutinate guinea ...

The integrin αvβ6 is an emerging biomarker for non-small cell lung cancer (NSCLC). An αvβ6-binding peptide was previously selected from a phage-displayed peptide library. Here, we utilize a multivalent design to develop a peptidic probe for positron emission tomography (PET) imaging of αvβ6+ NSCLC tumors. Multimeric presentation of this peptide, RGDLATLRQL, on a bifunctional copper chelator was...

Metoclopramide (MCP) is frequently used to treat gastroparesis. Previous studies have documented MCP metabolism, but systematic structural identification of metabolites has not been performed. The aim of this study was to better understand MCP metabolism in humans. For examination of in vivo metabolism, a single oral 20-mg MCP dose was administered to eight healthy male volunteers, followed by ...