INTRODUCTION Sir James Mackenzie (1852–1925) is known as ‘the father of general practice-based research’.2 From humble origins in rural Perthshire, Mackenzie overcame early social and educational hurdles to study medicine in Edinburgh, then pursued a career in general practice in Burnley. He initiated the systematic observation of his patients that led to his stellar research career, including ...

TiH Industrial Revolution transformed Burnley from a country town with a population of some 5,000 whose main occupations were sheep farming and the hand loom weaving of woollen cloth to one of almost 100,000 by the beginning of the present century. Factories, warehouses, foundries, workshops and coal mines had attracted the new labour force and the rapid influx was attended with appalling housi...

When Sir James Mackenzie was moving back to Scotland from London in 1918 to set up the Institute for Clinical Research in St Andrews he said that he wanted ‘To do for medicine what the Atomic Theory had done for chemistry’.1 He was referring to the fact that Sir Ernest Rutherford had ‘split the atom’ the year before and ushered in a new scientific age through nuclear fission. Mackenzie saw an a...

Introduction I FEEL highly honoured to give this James Mackenzie lecture at the conclusion of the Royal College of General Practitioners' 40th anniversary year and, like my predecessors, have found that one of the pleasures of its preparation has been rereading the biographies of Sir James Mackenziel and a few of his many publications. This man of humble Scottish origins, after many years of ge...

In the current work, we provide a formal Mackenzie-style persuasion dialogue for grounded semantics. We show that an argument is in the grounded extension iff the proponent is able to persuade a maximally sceptical opponent in the dialogue.

MY mother-in-law and father-in-law live happily together in Summerseat Lane, Holcombe Brook, near Bury in Lancashire. The address of the speaker's mother-in-law must surely be the most inauspicious piece of information with which any Mackenzie lecturer has ever begun. But you will see the relevance when I tell you that I set out this year on a bitingly cold January day from Summerseat Lane whic...

A partial steppe bison (Bison priscus) carcass was recovered at Tsiigehtchic, near the confluence of the Arctic Red and Mackenzie Rivers, Northwest Territories, Canada in September of 2007. The carcass includes a complete craniumwith horn cores and sheaths, several complete post-cranial elements (many of which have some mummified soft tissue), intestines and a large piece of hide. A piece of me...